过敏性猝死者咽喉和胃肠组织内P物质的表达  

Expression of Substance P in Human Laryngopharynx and Gastrointestine in Sudden Erethistic Death

作　　者：孙宏伟[1] 高彩荣[1] 任广睦[1] 孙俊红[1] 路健[1] 王英元[1] 

机构地区：[1]山西医科大学法医学院,山西太原030001

出　　处：《法医学杂志》2006年第3期180-182,F0004,共4页Journal of Forensic Medicine

基　　金：山西省青年科学基金资助项目(20031063)

摘　　要：目的观察P物质在过敏性猝死人体咽喉和胃肠组织的表达,并探讨其在法医学鉴定中的作用和意义。方法应用免疫组化方法对15例过敏性猝死者咽喉和胃肠组织的P物质表达进行研究,同时以冠心病猝死者作为对照;应用计算机图像分析系统对免疫组化染色结果进行分析,计算阳性指数(PI)。结果与对照组相比,实验组咽喉和胃肠组织P物质表达明显增加(P<0.001)。结论咽喉和胃肠组织的P物质表达可作为过敏性猝死的法医学鉴定的形态学依据和参考指标。Objective To study the expression of substance P （SP） in human sudden erethistic death, and to seek objective morphological supports to diagnose sudden erethistic death for forensic medicine. Methods The expression of SP was detected with immunohistochemical technique on 15 human laryngopharynx and gastrointestine of sudden erethistic death, and 20 sudden death of heart attack as control. The images of SP were analyzed by image analyzer, and the positive indexes（PI） were calculated. Results SP expression in the experimental groups was significantly stronger than that in the control one （P〈0.001）. Conclusion SP expression can offer an objective morphological reference support for forensic diagnosing sudden erethistic death.

关 键 词：P物质 过敏性猝死 免疫组化 

分 类 号：R338[医药卫生—人体生理学] R285.5[医药卫生—基础医学]