男性2型糖尿病患者血清瘦素水平与肥胖关系的探讨  

An Investigation on the Correlation between Leptin Level and Obesity in Male Subjects with Type 2 Diabetes

作　　者：王苏苏[1] 张昭馥[1] 王小红[2] 

机构地区：[1]海军总医院干三科,北京100037 [2]海军指挥学院门诊部,南京210016

出　　处：《海军总医院学报》2006年第2期79-82,共4页Journal of Naval General Hospital of PLA

摘　　要：目的观察男性2型糖尿病患者血清瘦素水平与肥胖之间的关系。方法用酶联免疫测定法测定男性糖尿病患者及对照组血清瘦素和真胰岛素水平。结果男性糖尿病组与非糖尿病组血清瘦素水平未见显著性差异(P>0.05),而肥胖个体的血清瘦素水平高于非肥胖个体(t=3.5,P<0.01),与体重指数呈正相关;男性肥胖组血清真胰岛素平均值高于非肥胖组(t=2.19,P<0.05),与血清瘦素水平及体重指数均呈明显的正相关(P<0.01和<0.001)。结论本研究结果提示:血清瘦素水平与糖尿病无直接相关性,而与人体肥胖程度密切相关。Objective To investigate the correlation between leptin level and obesity in male subjects with type 2 diabetes. Methods The Serum leptin concentration was measured using enzyme-linked immunosorbents assays（ELISA）. Results There were no significant differences between the serum leptin concentrations in diabetics and in non-diabetics（P〉0. 05）. The serum leptin levels of obese subjects in both diabetic and nondiabetic groups were significantly higher than that in non-obese subjects（t=3.50,P〈0.01）, and showed good correlation with BMI（r=0. 5106, P〈0.01）. The serum insulin concentrations of obese subjects were also higher than that of non-obese subjects（t=2.19, P（0. 05）. The serum leptin levels in male obese subjects were positively correlated with serum specific insulin concentrations and BMI（P〈0. 01 and P〈0. 001）. Conclusion The serum leptin level had no direct relationship to diabetes, but was significantly associated with obesity.

关 键 词：糖尿病 瘦素 肥胖 

分 类 号：R587.1[医药卫生—内分泌]