氧氟沙星控释人工骨的制备及释药机理的探讨  

PREPARATIN OF RELEALING CONTROLLED OFLOXACIN POROUS HYOLROXYAPATITE AND RELEASING MECHANISM

作　　者：景利[1] 曾仁杰[1] 刘明蓉[1] 孙伟张[1] 青磊[1] 刘丰丰[1] 

机构地区：[1]成都军区总医院

出　　处：《华西药学杂志》1996年第3期137-139,共3页West China Journal of Pharmaceutical Sciences

摘　　要：以蜂蜡和乙基纤维素为阻滞剂，包裹羟基磷灰石生物陶瓷人工骨（ＰＨＡ）．内载药物氧氟沙星（ＯＦＬＸ），制成氧氟沙里控释人工骨（ＯＦＬＸ－ＰＨＡ）．对ＯＦＬＸ－ＰＨＡ进行了体外释药量实验。探讨ＰＨＡ包裹阻滞剂后，药物ＯＦＬＸ的释放规律，以及影响ＯＦＬＸ－ＰＨＡ释药速率的因素。Releasing controlled ofloxacin porous hydroxyapatite(OFLX-PHA) was prepared with wax and efhylcellulose as aretardant.porous hydroxylapatite asa carrier.Experiment of drug-releasing in vitro was made.The drug-releasing mechanism and its affecting-factor of OFLX-PHA was investigated.

关 键 词：羟基磷灰石 陶瓷人工骨 氧氟沙星 体外释药 

分 类 号：R978.19[医药卫生—药品] R318.17[医药卫生—药学]