组织细胞性坏死性淋巴结炎中EBV-LMP-1、Fas/Fas-L的表达  

Expression of EBV-LMP-1, Fas/Fas-L in histiocytic necrotizing lymphadenitis

作　　者：赵晓红[1] 纪祥瑞[2] 

机构地区：[1]山东省青岛市人民医院病理科,青岛266021 [2]青岛大学医学院病理学教研室,青岛266021

出　　处：《临床与实验病理学杂志》2006年第3期274-276,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨EB病毒、Fas/Fas-L在组织细胞性坏死性淋巴结炎(histiocytic necrotizing lymphadenitis,HNL)发生、发展中的作用及相互关系。方法应用免疫组化SP法检测40例HNL和10例反应性增生淋巴结组织中的CD8、EB病毒编码的隐伏膜蛋白(EBV-LMP-1)、Fas、Fas-L蛋白的表达状况。结果LMP-1、Fas/Fas-L在HNL的表达均比对照组明显增高(P<0·05)。EBV-LMP-1的表达与Fas/Fas-L呈正相关(P<0·05)。结论EB病毒是HNL的发病原因之一,Fas/Fas-L介导的细胞毒性反应为引起EB病毒感染淋巴细胞凋亡的主要原因之一。Purpose To study the roles and relationship of EBV-LMP-1, Fas/Fas-L in the pathogenesis of histiocytic necrotizing lymphadenitis（HNL）. Methods The expression of CDS, EBV-LMP-1, Fas/Fas-L was detected by SP immunohistochemical staining in 40 cases of HNL and 10 cases of reactive hyperplastic lymphadenopathy. Results The positive expression of EBV-LMP-1, Fas/Fas-L was obviously higher than that in the control （ P 〈 0. 05 ）. There was positive relationship between the expression of EBV-LMP-1 and Fas/Fas-L （ P 〈 0. 05 ）. Conclusions Pathogenesis of HNL is related to EB virus. Fas-based and T-cell-mediated cytotoxicity is the main mechanism of the apoptosis of EBV infected cells in HNL.

关 键 词：HNL 爱波斯坦-巴尔病毒 Fas FAS-L 细胞凋亡 免疫组织化学 

分 类 号：R551.2[医药卫生—血液循环系统疾病]