COX-2、VEGF在子宫腺肌病中的表达及临床意义  

Expression and significance of COX-2 and VEGF in adenomyosis

作　　者：叶飞[1] 张静[1] 覃建庆[1] 朱志洁[1] 徐荣春[1] 陈丽春[1] 秦立波[1] 

机构地区：[1]大庆油田总医院妇产科,黑龙江大庆163001

出　　处：《哈尔滨医科大学学报》2006年第3期233-235,共3页Journal of Harbin Medical University

摘　　要：目的探讨环氧化酶2(COX-2)和血管内皮生长因子(VEGF)在子宫腺肌病中异位内膜及在位内膜中的表达及其临床意义。方法应用免疫组化法检测COX-2和VEGF在子宫腺肌病在位内膜、异位内膜和正常内膜中的表达。结果①VEGF在子宫腺肌病异位、在位内膜中的表达较正常内膜组明显增强,差异均有统计学意义(P均<0.05);异位内膜组与在位内膜组间VEGF表达差异无统计学意义(P>0.05)。②COX-2在子宫腺肌病异位内膜、在位内膜中的表达与正常子宫内膜组间比较差异均有统计学意义(P均<0.05);异位内膜组与在位内膜组间COX-2表达差异无统计学意义(P>0.05)。③COX-2和VEGF在子宫腺肌病患者异位内膜组中的表达呈正相关(P<0.05)。结论COX-2和VEGF是参与调控血管生成最重要的血管生长因子,提示血管生成在子宫腺肌病的发生、发展过程中可能发挥重要作用。Objective To discuss the expression of Cyclooxygenase-2（COX-2） and vascular endothelial growth factor （VEGF） in adenomyosis and its clinical significance. Methods Using immunohistochemistry SP method, the expression of COX-2 and VEGF was examined in ectopic endometrium and eutopic endometrium, compared with normal endometrium. Results ①VEGF could be expressed either in endometriumal glands or stromal cells. VEGF expressions in ectopic, eutopic endometrium with adenomyosis were both significantly higher than that of control group （ P 〈 0.05） ; no statistically significant difference was found between ectopic endometrium and eutopic endometrium group（ P 〉 0.05）. QCOX-2 could be expressed either in endometriumal glands or stromal cells. COX-2 expression in ectopic, eutopic endometrium with adenomyosis was significantly higher than that in control group （ P 〈 0.05）. No statistically significant difference was found between ectopic endometrium and eutopic endometrium group with adenomyosis （P 〉 0.05）. （3）VEGF and COX-2 had the positive relativity in the ectopic endometriumal expression of adenomyosis patient （ P 〈 0.05）. Conclusion COX-2 and VEGF are important cellular factors of promoting vascular formation. Data demonstrate that they could probably play important roles in the pathogenesis of adenomyosis.

关 键 词：子宫腺肌病 环氧化酶2 血管内皮生长因子 

分 类 号：R711.74[医药卫生—妇产科学]