固环止血胶囊对置IUD大鼠血浆及子宫组织ET和TXB_2的影响  

Effect of Guhuan Hemostatic Capsule(固环止血胶囊) on ET and TXB_2 in plasma and uterus homogenate of intrauterine device placed Rat

作　　者：秦大莲[1] 陈美娟[1] 李晓冰[1] 李万平[1] 刘明华[1] 

机构地区：[1]泸州医学院药理教研室,泸州646000

出　　处：《中药药理与临床》2006年第3期149-150,共2页Pharmacology and Clinics of Chinese Materia Medica

基　　金：四川省计生委资助项目(No.98-4-8)

摘　　要：目的:研究固环止血胶囊对放置宫内避孕器(IUC)大鼠血浆及子宫组织内皮素(ET)和血栓烷(TXB2)的影响。方法:采用放射免疫法测血浆及子宫匀浆ET和TXB2。结果:固环止血胶囊高剂量组血浆及子宫组织内ET和TXB2分别为(198.90±31.31)、(359.23±61.34)pg/m l和(152.50±21.38)、(48.63±7.70)pg/m l,与模型组[(119.22±48.34)、(218.06±40.52)和(100.92±29.00)、(31.03±7.3)pg/m l]比较有统计学意义(P<0.05)。结论:固环止血胶囊止血作用与增加大鼠血浆及子宫组织内ET和TXB2的含量有关。Objective： To study effect of guhuan hemostatic capsule on ET and TXB2 in plasma and uterus homogenate of intrauterine device placed rat. Methods： By means of radio-immunity to test ET and TXB2 in plasma and uterus homogenate of rat. Results： In high dose guhuan hemostatic capsule group, ET and TXB2 in plasma and uterus homogenate are 198.90±31.31, 359.23±61.34 pg/ml and 152.50±21.38, 48.63±7.70 pg/ml respectively, there are statistics significance（p 〈 0.05）compared with model group（119.22±48.34, 218.06±40.52 pg/ml and 100.92±29.00, 31.03±7.33 pg/ml）. Conclusion： Hemostatic action of Guhuan hemostasia capsule has to do with increase of ET and TXB2 in plasma and uterus homogenate.

关 键 词：固环止血胶囊 宫内避孕器 大鼠 内皮素 血栓烷B2 

分 类 号：R285[医药卫生—中药学]