赶山鞭黄酮抗免疫性炎症作用机制的初步研究  

Preliminary research on the mechanism of flavonids derired from Hypericum attemuatum against immnue inflammation

作　　者：董建勇[1] 贾忠建[2] 

机构地区：[1]温州医学院药学院,浙江温州325035 [2]兰州大学功能有机化学国家重点实验室,甘肃兰州730000

出　　处：《温州医学院学报》2006年第3期189-191,共3页Journal of Wenzhou Medical College

基　　金：国家博士后基金资助项目(200115194)。

摘　　要：目的:研究赶山鞭黄酮抗免疫性炎症作用机制。方法:复制大鼠AA模型,通过足容积测量,外周血细胞因子IL-1β、TNF-α测定,脾细胞增殖试验,胸腺、肾上腺脏器指数,分析赶山鞭酮抗免疫性炎症作用机制。结果:与致炎模型组相比,赶山鞭黄酮能减轻AA大鼠左、右后足炎症(P<0.01);降低血清中细胞因子IL-1β、TNF-α的含量(P<0.01,P<0.05)。结论:赶山鞭黄酮有较好的抗炎作用,其降低血清中细胞因子IL-1β、TNF-α的水平可能是抗炎作用机制之一。To study the mechanism of flavonids from Hypericnm attemuatum against immune inflammation. Methods： Rat immunized by Freund＇s adjuvant were treated with fiavonids from Hypericum attemuatum. Volumes of toe, IL-1β and TNF-α in serum, spleen T lymphocyte proliferation response, thymus index and adrenal gland index were detected. Results： Compared with control group, flavonids from Hypericnm attemuatum relieved the inflammatory swelling of toe（P〈0.01）, decreased the level of IL-1β （P〈0.01）, and TNF-α （P〈0.05） in serum. Conclusion： Flavonids from Hypericum attemuatum can perfectly affect anti-inflammatory effed. Decreasing the level of IL-1 β　and TNF-α in serum, may be one of the mechanism of anti-inflammatory function.

关 键 词：赶山鞭 黄酮 免疫性炎症 抗炎作用 

分 类 号：R931.6[医药卫生—生药学]