甲亢^(131)碘治疗对血清降钙素的影响  

The Changes of Serum Calcitonin Concentration in Hyperthyroidism Patients Treated with￣^(131)Iodine

作　　者：黄春福[1] 刘健[1] 吴继琮[1] 付洪亮 

机构地区：[1]上海第二医科大学附属新华医院核医学科

出　　处：《上海第二医科大学学报》1996年第4期243-245,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：作者观察２０例甲亢患者：１３１Ｉ治疗前后及随访中血清降钙素（ＣＴ）含量变化。其中８例发生甲减的患者治疗前后血清ＣＴ分别为１９．７６±３．５ｐｇ／ｍｌ、１１．０６±２．０９ｐｇ／ｍｌ，Ｐ＜０．０５；与１２例甲状腺功能恢复正常的患者其治疗前后血清ＣＴ比较分别为１１０６±２．０９ｐｇ／ｍｌ、２４．８４±８．１ｐｇ／ｍｌ，Ｐ＜０．０１。甲减患者中６例服用于甲状腺素片前后的血清ＣＴ水平比较无明显变化。研究提示：甲亢经１３１Ｉ治疗后发生甲减的患者导致ＣＴ分泌降低。补充外源性甲状腺素只能纠正其甲减状态，不能帮助甲状腺组织修复。“Ｃ”细胞合成分泌ＣＴ的功能必须依赖于正常甲状腺组织。The Serum calcitonin(CT)levels in 20 cases of hyperthyroidism before and after radioiodine therapy were compared.In cases with hypothyroidism status(n=8) the mean serum CT levels were reduced from l9.76±3.5pg/ml to 11.06±2.09 pg/ml(P<0.05).In cases with euthyroid status(n=12)the mean serum CT Ievels were 24.84±8.1pg/ml.There was a significant difference of serum CT levels between hypothyroid euthyroid status(P<0.01).There was no significant change of CT Ievel in hypothyroidism cases received desiccated thyroid treatment.There data suggested that in hyperthyroidism patients with post radioiodine therapy hypothyroidea status CT excretion from thyroid tissue seems to be decreased,mean while,the CT synthesis by C-cells appeares to be depended on the activity of thyroid tissue. However,the use of desiccated thyroid could be improved hypothyroiea status but the damaged thyroid tissue might be remained persistenthy.

关 键 词：^(131)碘 甲亢 甲减 血清降钙素 

分 类 号：R581.105[医药卫生—内分泌]