囊胚期与卵裂期胚胎培养与移植比较  

Analysis of Effectiveness of Embryo Transfer Compared with Embryo Transfer

作　　者：铁新琴[1] 杨如镜[1] 

机构地区：[1]郑州大学第三附属医院生殖医学中心,郑州市450052

出　　处：《医药论坛杂志》2006年第10期3-5,共3页Journal of Medical Forum

摘　　要：目的分析早期卵裂期与囊胚期胚胎培养与移植结局。方法选取因单纯输卵管因素及男性因素接受体外受精-胚胎移植患者,其中选择卵裂期胚胎移植者110例,选择囊胚期胚胎培养与移植者57例。受精后早期胚胎培养采用G1,囊胚培养采用G2。比较两组的获卵数、受精数、胚胎植入率、妊娠率以及囊胚组囊胚形成率、移植胚胎数与多胎率、妊娠率的关系。结果囊胚组获卵率、受精率分别比早期胚胎组多4.98及3.98个;采用G1/G2序贯培养,囊胚形成率为32.9%;两组胚胎植入率、临床妊娠率分别为31.2%、42.1%及11.5%、25.5%,囊胚组明显高,差异有显著性;移植2个囊胚与移植3个囊胚比较,妊娠率无显著差异,但可减少双胎妊娠例数。结论囊胚期胚胎移植可明显提高胚胎植入率及妊娠率。移植两个囊胚为IVF-ET的最好选择。Objective To evaluate the effectiveness of the blastocyst culture and transfer compared with the cleavage stage transfer. Methods Patients were recruited into this study from those embarking on IVF treatment for the reasons of fallopian tube and male infertility. The cleavage stage transfers were performed on 110 cases and the blastocyst cultures and transfers on 57 cases. The numbers of obtaining and fertilized ovum, embryonic implantation and clinical pregnant rates as well as the blastocyst formation rate, the relationship between the embryo numbers of each transfer and the multiplets and clinical pregnant rates were evaluated. Results The numbers of obtaining and fertilized ovum rates in the blastocyst group was higher than that in the blastocyst group （4. 98 and 3.98, respectively）. The blastocyst formation rate was 32. 9% using G1/G2 sequential culture media. The embryonic implantation rate and clinical pregnant rates were significantly higher in the blastoeyst group than that in the cleavage stage group （31.2% ,42. 1% and 11.5% ,25.5% ,respectively）. There was no significantly difference between transfer 2 or 3 blastocystes. It appears that the numbers of twins was reduced in transfer 2 blastocystes. Conclusion The results of our study confirmed that the blastocyst transfer has more advantages than the cleavage stage transfer in rising the embryonic implantation rate and clinical pregnant rate. Transfer 2 blastocyst is best choice for IVF - ET.

关 键 词：囊胚 胚胎移植 体外受精 

分 类 号：R321.2[医药卫生—人体解剖和组织胚胎学]