环境激素邻苯二甲酸丁基苄酯的动力学  

Dynamics of environmental hormone butylbenzyl phthalate

作　　者：李文兰[1] 季宇彬[1] 姜安玺[2] 吕东阳[1] 杨波[1] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨150076 [2]哈尔滨工业大学市政环境工程学院,哈尔滨150090

出　　处：《哈尔滨工业大学学报》2006年第6期982-985,共4页Journal of Harbin Institute of Technology

基　　金：黑龙江省博士后基金资助项目;国家教育部重点科研项目(2048);黑龙江省科学技术计划攻关项目(GC02C209)

摘　　要：采用同位素标记方法示踪环境激素邻苯二甲酸丁基苄酯的生物转运过程,用NDST21动力学处理软件判断房室模型,建立邻苯二甲酸丁基苄酯的数学模型,计算各种参数.实验结果表明:3H-BBP经口染毒后被迅速吸收,5 m in即在血中检测出,0.5 h达高峰,并呈一级动力学线性过程,符合二室开放模型;测得吸收半衰期约为13 m in,分布半衰期约为25 m in,消除半衰期约为7 h,说明该化合物的吸收和分布较快、消除较慢;3H-BBP的主要排泄途径是从尿和粪中排泄,在4 d之内从尿和粪累计排泄量占染毒量80%左右.To study the biotransmission of environmental hormone butylbenzyl phthalate by isotope-labeling method, pharmacokinetic compartment model was evaluated by NDST21 software and mathematical model of butylbenzyl phthalate was set up to evaluate parameters. The results show ^3H-BBP is absorbed rapidly and detected in blood after 5 min, then its concentration reaches top at 0. 5 h. First-order linear equation and twocompartment open model are gained. The half life of absorption, distribution and elimination is respectively about 13 min, 25 min and 7 h, which indicates the absorption and distribution of this is compound quick and elimination is slow. ^3H-BBP is mainly excreted by urine and feces, and the excrement of ^3H-BBP accounts for 80% of total dose within 4 days.

关 键 词：环境激素 邻苯二甲酸丁基苄酯 动力学 

分 类 号：R994.6[医药卫生—毒理学]