铜绿假单胞菌产β-内酰胺酶研究进展  

The advance of β-lactamases produced by pseudomonas aeruginosa

作　　者：赵廷坤[1] 周岐新[1] 凌保东[2] 

机构地区：[1]重庆医科大学药理教研室,400016 [2]川北医学院药物研究所,南充637007

出　　处：《国际流行病学传染病学杂志》2006年第3期211-214,共4页International Journal of Epidemiology and Infectious Disease

基　　金：四川省教育厅自然科学科研重点项目(2004A071)

摘　　要：铜绿假单胞菌产β_内酰胺酶是其对β_内酰胺类抗生素耐药的主要机制,所产β_内酰胺酶种类繁多、特性各异,并在β_内酰胺类抗生素广泛应用的选择压力下,不断有新的β_内酰胺酶产生。文中对铜绿假单胞菌产β_内酰胺酶(ESBL、AmpC、金属酶)耐药机制的研究进展作了简要综述。The most important mechanism of resistance to β-lactam antibiotics is the β-lactamases produced by Pseudomonas aeruginosa, and the β-lactamases is different in catology and character and produce a new ones under Pseudomonas aerug/nosa that contain β-lactamases encounter simultaneous or consecutive selective pressure with different β-lactam molecules. This review describes the origin, evolution and characteristics of the β-lactamases produced by Pseudomonas aeruginosa.

关 键 词：Β-内酰胺酶 铜绿假单胞菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]