低浓度臭氧的一般生殖毒性试验  

General reproductive toxicity assessment in mice exposed to low-level ozone

作　　者：周智君[1] 周正适[1] 汤百争[1] 

机构地区：[1]中南大学实验动物学部,长沙410078

出　　处：《中南大学学报（医学版）》2006年第3期450-452,共3页Journal of Central South University ：Medical Science

基　　金：湖南省科技厅课题(2001湘科条字178)

摘　　要：目的：研究低浓度臭氧对小鼠是否具有生殖毒性作用。方法：实验组小鼠和对照组小鼠分别在15W紫外灯照射产生的低浓度（0.09-0.18mg／m^3）臭氧环境下和正常环境下连续饲养7周，之后进行交配实验，观察雌鼠受孕率和体质量变化，胎仔体质量、外观、内脏和骨骼情况等。结果：实验组和对照组各项指标均差异无统计学意义。结论：15W紫外灯照射产生的低浓度臭氧可能对昆明小鼠没有生殖毒性作用。Objective To explore the general reproductive toxicity in mice exposed to low-level ozone. Methods Low-level （0.09 - 0. 18 mg/m^3） ozone was created by 15 W ultraviolet light. The mice in 3 experimental groups and a control group were fed in low-level ozone environment or normal environment, respectively, and then the mating experiment was conducted. The pregnancy rate and the weight variations of the female mice were observed. The weight of the live fetuses was observed, and the appearance, bone and internal organs were checked for malformation. Results There were no significant differences in any indexes between the experimental groups and the control group. Conclusion Low-level ozone created by 15 W ultraviolet light may not have reproductive toxicity in mice.

关 键 词：臭氧 生殖毒性 小鼠 

分 类 号：R114[医药卫生—卫生毒理学]