云南省2152例HIV/AIDS流行特征及CD_4^+CD_8^+检测结果分析  

The Analysis on Epidemiological Characteristics and CD_4^+/ CD_8^+ Testing Results of 2 152 Cases With HIV/AIDS in Yunnan Province

作　　者：杨莉[1] 马艳玲[1] 杨朝军[1] 苏莹珍[1] 施玉华[1] 杨榆玲[1] 闫文云[1] 张光彩[1] 

机构地区：[1]云南省疾病预防控制中心,云南昆明650022

出　　处：《中国皮肤性病学杂志》2006年第6期356-358,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的了解云南省艾滋病流行特征。方法分析流行病学资料,应用流式细胞计数仪和三标TruCount荧光标记单克隆抗体试剂盒对2 152例H IV感染者/AIDS患者进行CD4、CD8检测。结果10~19岁组H IV/AIDS中女性占61.5%,暗娼占28.2%,远远大于其他年龄组。通过性途径传播的在50岁以上组中所占比例最大(52.6%),10~19岁组次之,占41.0%;2 144例中CD4+<200个/mL的有356例(16.6%),其中50岁以上龄组<200个/m l的占36.8%,10~19岁组中>350个/m l的占82.1%;AIDS患者CD4+、CD4+/CD8+低于H IV感染者(P<0.001和P<0.001),2 144例H IV/AIDS中CD4+/CD8+≥1的有41例,其中女性占51.2%,异性传播感染的占31.7%。结论目前云南省艾滋病病毒感染者虽然仍以注射吸毒人群为主,但性传播和母婴传播危险性加大。CD4+、CD4+/CD8+与临床进程明显相关,随着疾病的进展,CD4+、CD4+/CD8+持续降低。发现部分感染者CD4+/CD8+≥1,未倒置情况是否提示该组感染时间较短,其流行病学分析资料是否可为艾滋病的控制提供依据还有待进一步研究。Objective To survey the epidemiological characteristics of PLWHA in Yunnan Province. Methods Collecting epidemiological data and conducting CD4^＋CD8^＋ counts of 2 512 PLWHA by FACSCalibur with use of Tri Fluorescent labeled Antibody（ CD3 ,CD4^＋,CD8^＋） and TruCount tube. Results The proportion of female among 10 - 19 age group accounted for 61. 5%, and the proportion of underground prostitution accounted for 28.2%, much higher than that of other age groups. The proportion of sexual transmission route was highest among 50 and over group（ 52.6% ） ,the next age group was 10 - 19 （41.0%） ;as for CD4^＋/CD8^＋ testing results,356 persons （ 16.6% ） were found to have CD4^＋ count lower than 200/μL,among them,those aged 50 and over accounted for 36.8% , as for the 10 - 19 group, 82.1% of whom had CD4^＋ count higher than 350/μL; CD4^＋,CD4^＋/CD8^＋of AIDS patients is lower than that of HIV infected persons.41 persons were found to have CD4^＋/CD8^＋≥1 ,with female accounted for 51.2%, and heterosexual transmission accounted for 31.7%. Conclusion Although injecting drug useis still the main route of transmission in Yunnan ,the risk of sexual transmission and Mother to Baby Transmission increased. CD4^＋ ,CD4^＋/CD8^＋ is obviously relevant with clinic progress,which is getting down along with the clinic progress. Some PLWHA have the ratio of CD4^＋ to CD^8＋ over than i ,it need further research to understand if it is due to infected with HIV in recent time or other reasons.

关 键 词：艾滋病 流行特征 CD4^+/CD8^+T淋巴细胞 分析 

分 类 号：R512.91[医药卫生—内科学]