慢性碘过量对缺碘大鼠甲状腺形态的影响  

Effect of chronic excessive iodine on thyroid morphology of iodine-deficient rats

作　　者：崇巍[1] 陈威[2] 单忠艳[2] 金迎[2] 关海霞[2] 李玉姝[2] 张诺[2] 满娜[2] 佟雅洁[2] 于扬[2] 范晨玲[2] 张志瑜[3] 张晓平 滕卫平[2] 

机构地区：[1]中国医科大学附属第一医院急诊科,辽宁沈阳110001 [2]中国医科大学附属第一医院内分泌科内分泌研究所,辽宁沈阳110001 [3]中国医科大学公共卫生学院,辽宁沈阳110001 [4]河北省承德市卫生局,河北承德067000

出　　处：《中国现代医学杂志》2006年第12期1781-1785,共5页China Journal of Modern Medicine

基　　金：国家自然科学基金资助项目(39970350);美国中华医学基金会资助项目(98-688IITD)

摘　　要：目的研究慢性碘过量对缺碘Wistar大鼠甲状腺形态的影响。方法4周龄Wistar大鼠经低碘饲料喂养3个月建立缺碘大鼠模型,对其进行8个月的1倍、3倍和6倍补碘,补碘量分别对应于笔者前期流行病调查所见的3个农村社区的碘摄入水平,后两者为碘过量。观察缺碘大鼠经不同剂量补碘后甲状腺形态学的变化。结果在补充1倍、3倍和6倍碘8个月后,甲状腺碘含量增加,甚至高于非缺碘大鼠;甲状腺相对重量仍然未能回落至非缺碘大鼠水平。电镜下缺碘引起的内质网扩张和线粒体肿大在补碘后未见恢复,且随补碘剂量的增加,超微结构损伤呈现加重的趋势。结论对缺碘动物单纯补碘难以纠正基础缺碘引起的甲状腺损伤,甲状腺内碘潴留,甲状腺肿仍然存在,甲状腺可能处于亚临床病理状态。[Objective] To study the effect of chronic excessive iodine on thyroid morphology of iodine-deficient rats. [Methods] Iodine-deficient rat models were made by giving 4-week old rats iodine-deficient fodder for 3 months. These iodine-deficient rats were then supplemented for 8 months 1-, 3- and 6- fold iodine which corresponded to the 3 levels of iodine intake found in our epidemiological study in 3 rural communities, the latter two levels were iodine excessive. Then changes in thyroid morphology after iodine supplement were observed. [Results] After supplement of 1-, 3- and 6-fold iodine to iodine-deficient rats for 8 months. Thyroid iodine content increased to the level higher than non-iodine-deficient rats. thyroid relative weight decreased, but was higher than non-iodine-deficient ones. The ultrastructure injures of swelling mitochondria and dilating endoplasmic reticulum in epithelial cells of iodine-deficient thyroid did not recover, but became worse with iodine supplement increase. [Conelusion] Iodine supplement alone could not correct the injures resulting from iodine deficiency with iodine accumulating in thyroid and goiter remaining. A sub-pathological state of thyroid might occur.

关 键 词：碘 大鼠 甲状腺 

分 类 号：R332[医药卫生—人体生理学]