大黄提取片改善单纯性肥胖患者胰岛素敏感性的研究  

Effect of Refined Rhubarb on Sensitivity of Insulin in the Obese

作　　者：裴宁[1] 张烁[1] 李益明[1] 焦东海 

机构地区：[1]复旦大学附属华山医院内分泌科,上海200040 [2]上海市香山中医医院,上海200020

出　　处：《中国临床医学》2006年第3期439-442,共4页Chinese Journal of Clinical Medicine

基　　金：上海市卫生局科研基金课题课题编号:2002J003A

摘　　要：目的：观察大黄提取片(降脂1号片)对单纯性肥胖患者胰岛素敏感性的影响并探讨其机制。方法：符合1997年世界卫生组织肥胖诊断标准的27例单纯性肥胖患者。口服大黄提取片每次5片,每天3次,总疗程8周。测定治疗前后血糖、血脂和血浆胰岛素,及血清脂联素、瘦素和肿瘤坏死因子α(TNF-α)水平。结果：服用大黄提取片后患者体重明显减轻,胰岛素抵抗指数降低,血清脂联素水平增加,瘦素和TNF-α水平下降。结论：大黄提取片治疗能减轻患者体重,增加血清脂联素,降低瘦素和TNF-α,改善机体胰岛素抵抗状况。Objective：To explore the mechanism of Refined Rhubarb on improving insulin sensitivity. Methods：Twenty-seven obesity were recruited according to the Word Health Organiztion diagnosis criteria. Each patient was administrated with Refined Rhubarb 5 tablets rid for 8 weeks. Routln clinical assays, serum glucose, insulin and lipids were measured ,as well as serumadiponectin, leptin, and TNF-α. Results： Refined Rhubarb reduced the body weight , triglyceride, cholesterol, Elevated level of adiponectin , lowerd leptin and TNF-α in serum and improvedinsulin sensitiviy. Conclusion： Refined Rhubarb improve insulin sensitivity by the changes of some adipocytokines.

关 键 词：胰岛素敏感性 大黄提取片 肥胖 脂联素 瘦素 肿瘤坏死因子-α 

分 类 号：R259.87[医药卫生—中西医结合]