托吡酯治疗癫痫的应用剂量分析  

The Efficacy and Sofery of Topiram in Patients with Epilepsy

作　　者：林建设[1] 欧阳山丹[1] 

机构地区：[1]中国人民解放军第一七四医院,福建厦门361003

出　　处：《中国临床医学》2006年第3期510-511,共2页Chinese Journal of Clinical Medicine

摘　　要：目的：观察托吡酯治疗癫痫的临床疗效及不良反应,探讨治疗的理想给药模式。方法：199例癫痫患者按不同初始剂量及加量速度分为A组和B组。A组102例,初始剂量25mg/d,每周增量25～200mg/d后维持治疗12周；B组97例,初始刺量50mg/d,每周增量50～200mg/d后维持治疗12周。结果：A组总有效率及控制率分别为77.7%、42.1%,B组总有效率及控制率为76.2%、40.2%,两组相比无显著差异(P＞0.05)。B组比A组不良反应多,有显著差异(P＜0.05)。结论：对发作频率较稀的癫痫患者,最好选用小剂量起始并缓慢加量的治疗方法。Objective：To observe the clinical efficacy and adverse reaction（AR）of topiramate（TPM）in treatment of epilepsy, and to explore the optimal mode of administration. Methods：One hundred and ninety-nine patients with epilepsy were divided into two groups according to different starting dose and the rate of increasing dosage,Group A （102 cases）,the starting dose of TPM was 25 mg/d and the increasing dos-age per week was 25 rng until 200mg/d was reached and then maintained for 12 wks;Group B（97 cases） ,the starting dose of TPM was 50mg/d and the increasing dosage per week was 50 rng until 200mg/d was reached and then maintained for 12 weeks. Restllts：The total effective rate and controlrate in Group A were 77. 7% and 42. 1% ;whereas those in Group B were 76. 2 and 40. 2 , respectively. Significant difference was found between both groups（P 0.05）. More ARs were observed in Group B as compared with Group A （P〈0. 05）. Conclusion：A small starting dose followed by slowly increasing dosage is recommended to patients with lower seizure frequency.

关 键 词：癫痫 抗惊厥药 

分 类 号：R645.2[医药卫生—外科学]