息痛颗粒对犬脑血流量和血压的影响  

Effects of Xitong Granule on the Blood Pressure and Brain Blood Flow in Dogs

作　　者：吴红霞[1] 冯国清[1] 巴玉峰[1] 胡香杰[1] 李永军[1] 王振基[1] 

机构地区：[1]郑州大学医学院药理教研室,河南郑州450052

出　　处：《河南职工医学院学报》2006年第3期175-177,共3页Journal of Henan Medical College For Staff and Workers

摘　　要：目的观察息痛颗粒对犬脑血流量和血压的影响。方法将犬随机分为5组,每组4只。分别为:空白对照组,尼莫地平组(6.2 mg.kg-1),镇脑宁组(37.26 mg.kg-1),息痛颗粒高剂量组(1.29 g.kg-1),息痛颗粒低剂量组(0.25 g.kg-1)。经十二指肠给药,以尼莫地平和镇脑宁作阳性对照药,观察记录给药前后脑血流量和血压的变化。结果息痛颗粒高剂量显著增加犬脑血流量(P<0.05),显著降低血压(P<0.05);息痛颗粒低剂量显著减少脑血流量,对血压无明显影响。结论息痛颗粒低剂量减少犬脑血流量,对血压无明显影响,高剂量显著增加犬脑血流量,降低血压。Objective To observe the effects of Xitong Granule on the blood pressure （BP） and brain blood flow （BBF） in dogs. Methods Twenty healthy dogs were divided randomly into 5 groups：control group （ no treatment ）, nimodipine group （6.2 mg· kg^- 1 ） , Zhennaoning Capsule group （37.26 mg· kg^-1, administrated through duodenum）,high dose of Xitong Granule group （1.29 g· kg^-1 ,administrated through duodenum）, low dose of Xitong Granule group （0.25 g· kg^-1, administrated through duodenum）. BP and BBF were evaluated in every dog before and after administration, respectively. Results and Conclusion Xitong Granule at low dose significantly decreased BBF and had no significant effects on BP. However, when administrated at high dose, it significantly increased BBF and decreased BP.

关 键 词：息痛颗粒 脑血流量 血压 

分 类 号：R285.5[医药卫生—中药学]