慢性肾衰患者血清IL-18、IL-10、sIL-2R、TNF-α水平变化  

Changes of Serum Levels of Several Cytokines(IL-8,IL-10,sIL-2R,TNF-α)in Patients with Chronic Renal Failure

作　　者：齐法莲[1] 徐军[1] 武翠华[1] 陈英剑[1] 贾文才 

机构地区：[1]济南军区总医院实验诊断科,250031 [2]济南军区456医院,250031

出　　处：《放射免疫学杂志》2006年第3期178-179,共2页Journal of Radioimmanology

摘　　要：目的:研究CRF患者血清IL-18、IL-10、TNF-α、sIL-2R的水平变化及临床意义。方法:分别采用R IA和ELISA法检测CRF患者血清IL-18、IL-10、TNF-α、sIL-2R含量,并与正常对照组比较分析。结果:CRF患者血清IL-18、IL-10、TNF-α、sIL-2R明显高于正常对照组(P<0.01)。结论:CRF患者多种细胞因子水平升高,血清IL-18和TNF-α水平升高提示了CRF的发生发展过程,而IL-10和sIL-2R升高则对其肾脏功能有一定的保护作用。Objective To study the clinical significance of changes of serum IL - 18, IL - 10, sIL - 2R and TNF - α levels in pa- tients with chronic renal failure （CRF）. Methods Serum IL - 18, slL - 2R （ with ELISA） and IL - IO,TNF -α （ with RIA） levels were measured in 37 patients with CRF and 30 controls, Results Serum levels of all these four cytokines were significantly higher in patients with CRF than those in controls （P 〈0. 01 ）. Conclusion Elevation of serum IL - 18 and TNF -α levels in patients with CRF might play a role of aggravation of the disease process, while elevation of IL - 10 and sIL -2R levels might be protective.

关 键 词：慢性肾功能衰竭 白细胞介素-18 白细胞介素-10 肿瘤坏死因子-α 可溶性白细胞介素-2受体 

分 类 号：R753.9[医药卫生—皮肤病学与性病学] R512.62[医药卫生—临床医学]