检测唾液中特异性抗体诊断人体旋毛虫病的研究  

Studies on diagnosis of human trichinellosis by detecting saliva specific antibodies

作　　者：申丽洁[1] 周群[2] 李伟[1] 罗志勇[3] 

机构地区：[1]大理学院基础医学院,大理671000 [2]保山市人民医院儿科,保山6780003 [3]大理学院临床医学院,大理671000

出　　处：《国际医学寄生虫病杂志》2006年第3期116-118,共3页International JOurnal of Medical Parasitic Diseases

基　　金：云南省卫生厅(99Q045);大理学院学术带头人基金资助

摘　　要：目的探讨检测唾液特异性抗体对人体旋毛虫病的诊断价值。方法用ELISA测定57例旋毛虫病人唾液中旋毛虫IgG抗体,并与血清同种抗体检测结果进行比较。结果检测唾液中旋毛虫IgG抗体诊断旋毛虫病的敏感性为64.91%,特异性为100%;检测血清旋毛虫IgG抗体诊断旋毛虫病的敏感性和特异性分别为91.23%和95.83%;唾液旋毛虫IgG与血清旋毛虫IgG的OD值呈正相关(r=0.4011)。结论检测唾液中特异性抗体对于诊断人体旋毛虫病有一定的应用价值,在采集血清有困难时可将唾液作为血清的替代检测标本。Objective To study the diagnostic value of detecting specific antibody in saliva of triehinellosis patients. Methods Saliva and serum anti-Trichinella antibodies （IgG） collected from 57 trichinellosis patients were assayed by ELISA. Results The sensitivity and specificity of saliva anti-Trichinella antibodies for diagnosis of trichinellosis were 64.91% and 100%, respectively. The sensitivity and specificity of serum anti-Trichinella antibodies were 91.23% and 95.83%, respectively. The OD value of saliva anti- TrichineUa antibodies was closely correlated with that of serum anti-Trichinella antibodies （r = 0. 4011 ）. Conclusion The detection of saliva specific antibodies could be used for the diagnosis of human trichinellosis when a serum sample was not obtainable.

关 键 词：旋毛虫病 唾液 抗体检测 免疫诊断 

分 类 号：R392-33[医药卫生—免疫学] R532.14[医药卫生—基础医学]