强化治疗对初诊糖尿病患者炎性因子的影响  

Effect of intensive insulin therapy on serum inflammatory factors in newly onset diabetic patients

作　　者：沈备[1] 冯佳庆[1] 徐宽枫[1] 刘超[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2006年第8期617-619,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:观察胰岛素每日多点注射(MDI)和持续皮下胰岛素输注(CSII)对初诊断2型糖尿病患者体内C反应蛋白(CRP)和细胞间黏附因子-1(ICAM-1)的影响。方法:将38名初诊的2型糖尿病患者随机分为两组,分别进行CSII和MDI方案强化治疗1个月,采用酶联免疫法分别测定比较治疗前后两组CRP和ICAM-1水平。结果:初诊的2型糖尿病患者采用CSII和MDI方案强化治疗后,CRP水平均显著降低,由治疗前2044.82±1801.93ng/ml、3167.73±1960.00ng/ml分别下降为1540.49±1205.29ng/ml、2014.10±1600.40ng/ml,但两组间比较无统计学差异;治疗后,两组ICAM-1水平均有下降趋势,但都无统计学意义。结论:初诊断的2型糖尿病患者采用两种强化治疗方案均可在良好控制血糖的同时有效降低CRP水平。Objective： To investigate the effects of intensive insulin therapy on the inflammatory factors in newly onset diabetics. Methods： Thirty-eight newly diagnosed diabetic patients were divided into multiple daily insulin injection group （MDI） and CSⅡ group. All patients were treated with insulin for one month. Serum C-reactive protein（CRP） and intercellular adhesion molecule-Ⅰ （Ⅰ- CAM-I ） were measured using enzyme-linked immunosorbent assay（ELISA） before and after insulin treatment. Results： After insulin therapy, the serum CRP level in the two groups was significantly decreased from 2 044.82 ± 1 801.93 ng/ml or 3 167.73 ± 1 960.00 ng/ ml to 1 540.49 ± 1 205.29 ng/ml or 2 014.10 ± 1 600.40 ng/ml,respectively, while there was no difference between two treatment groups. The level of ICAM-1 was reduced （P 〉 0.05 ）. Conclusion： Intensive insulin therapy can effectively control the blood glucose in newly onset diabetics receiving MDI or CSII regimen. Serum inflammatory factor CRP may be reduced with both intensive insulin therapy protocols.

关 键 词：糖尿病 胰岛素 C反应蛋白 

分 类 号：R587.1[医药卫生—内分泌]