钻孔修复兔关节软骨缺损的实验研究  

SUBCHONDRAL BONE DRILLING FOR REPAIR OF ARTICULAR CARTILAGE DEFECTS-AN EXPERIMENTAL STUDY IN RABBITS

作　　者：葛志强[1] 雷学锋[1] 杨洪锋 曹化祥[1] 王宝生[1] 廉平[1] 叶建[1] 刘启龙[1] 祝海州[1] 

机构地区：[1]济宁医学院外科学教研室

出　　处：《济宁医学院学报》1996年第1期1-5,共5页Journal of Jining Medical University

基　　金：中华医学基金

摘　　要：为了观察软骨缺损的修复过程，比较不同数目钻孔术对软骨缺损的修复效果，用中国白兔２４只，在股骨关节面造成６ｍｍ×８ｍｍ全层软骨缺损，分别施行１０孔和５孔钻孔术，术后４、８周取材，做组织学及电镜观察，并进行评估。结果表明：１０孔、５孔和对照组的优势修复组织分别为类透明软骨、幼稚软骨加纤维软骨和纤维组织。修复组织厚度１０孔和５孔无显著差异。修复组织覆盖缺损的面积，１０孔＞５孔＞对照组。初步结论：软骨下骨钻孔可修复关节软骨全层缺损；多孔比少孔修复效果好；非钻孔的缺损修复效果较差。In order to observe the procees of articular cartilage defect repairing and compare the effect of repairing after subchondral drilling with different numbers of holes, full-thickness defects of 6mm×8mm were created over the articular surface of both the femoral condyles in 24 rabbits. 10 holes and 5 holes were drilled respectively over the defects with the exception of those of the control group. They were sacrificed postoperatively at the end of 4 and 8 weeks.The newly formed tissues in the defects were examined histologically and ultrastructurally. The effects of defect repair in different groups were compared and evaluated. The results were as follows. Hyalin-like cartilage was formed in the 10-hole group, immature cartilage or fibrous cartilage was identifid in the 5-hole group, and fibrous tissues were found in the controls, The thickness of repaired tissues had no significant difference between the 10-hole and 5-hole groups. The covered area of repaired tissue of the 10-hole group exceeded that of 5-hole and control groups. It is preliminarily concluded that subchondral bone drilling is feasible for repairing full-thickness articular cartilage defects. The repair effect with more noles is superior to that with less holes. When the defects are not drilled, the tissue regeneration is much less and the repair insufficient.

关 键 词：关节软骨 软骨缺损 软骨下骨钻孔术 

分 类 号：R681.3[医药卫生—骨科学]