电刺激终纹床核群对大鼠痛阈的影响  

EFFECTS OF ELECTRICAL STIMULATION OF BED NUCLEI OF STRIA TERMINALIS ON PAIN THRESHOLD IN THE RAT

作　　者：张道启[1] 韩先芹[1] 王曙光[1] 闫瑞臻[1] 白波[1] 黄其鄂 陈婉梅[1] 

机构地区：[1]济宁医学院生理学教研室,济宁市卫生学校,西安医科大学

出　　处：《济宁医学院学报》1996年第1期6-8,共3页Journal of Jining Medical University

基　　金：山东省卫生厅青年基金

摘　　要：本实验用辐射热作为伤害性刺激，以浅麻状态大鼠甩尾反射潜伏期为痛阈指标，观察了电刺激终纹床核群对大鼠痛阈的影响。结果表明，电刺激终纹床核群使大鼠甩尾反射潜伏期明显延长；这种作用可被ＰＡＧ内微量注入γ－氨基丁酸所阻断。提示终纹床核群参与了痛觉调制，其下行抑制通路主要是经过ＰＡＧ中继的。The tail-flick latency(TFL) in lightly pentobanbital-anesthetized rat by nociception stimuli with radiant heat was measured as pain thresold. Effects of electrical stimulation of the bed nuclei of stria terminalis(BST) on the pain threshold were investigated. It was found that TFL was increaed(P<0.05) at once after BST was stimulated, but it returned to normal in 5min. The effects of BST stimulation on tail-flick reflex were blocked by mioroinjection of GABA into PAG. The results suggest that BST plays an impotant role in pain modulation and the decending inhibitory pathway of BST-induced antinociception is mainly mediated via a relay though the PAG.

关 键 词：终纹床核群 痛觉调制 甩尾反射 PAG 大鼠 

分 类 号：R338.8[医药卫生—人体生理学]