骨康冲剂对骨质疏松症BMD、BGP、PYD、E_2、T的干预  

Effects of Gukang granules on BMD,BGP,PYD,E_2 and T in osteoporosis

作　　者：杜莹[1] 邵敏[1] 陈小华[1] 刘庆思[1] 

机构地区：[1]广州中医药大学第三附属医院,510240

出　　处：《中国骨质疏松杂志》2006年第3期283-285,共3页Chinese Journal of Osteoporosis

摘　　要：目的运用补肾健脾活血的代表方剂—骨康冲剂治疗原发性骨质疏松的疗效观察证明补肾健脾活血法的临床意义。方法原发性骨质疏松症80例,随机分为骨康冲剂治疗组、强骨胶囊对照组对照观察。结果骨康冲剂治疗组总有效率达96%,显效率达72%。治疗后比治疗前骨密度提高了,临床症状有明显改善、肾虚积分均有明显下降、但两组无明显差异,血清骨钙素(BGP)显著上升,尿吡啶酚(PYD)显著下降。以上指标两组均无差异。结论骨康冲剂具有促进骨形成,抑制骨吸收的作用。对防治骨质疏松症有效,并说明补肾健脾活血法对防治骨质疏松症有实用价值。Objective To clarify the clinical significance of the synthesized recipes of Kidney Nourishing Recipe （KNR） ,Invigorating Spleen Recipe（ISR）, and Promoting Blood Circulation Recipe （PBCR） by observation the clinic effect of GuKang Granules （GGs）, the representative herb of KNR, ISR and PBCR on primary osteoporosis patients. Methods Eighty patients with primary osteoporosis were randomly divided into two groups： the active group of GGs and the control group of QiangGu capsules. Results The effective rate of active group was 96 % and the bone mineral density（BMD） had been increased, the clinic symptoms allieviated, and the scores of renal deficiency decreased, but no significant difference was found between the two groups. The active groups＇s bone gla protein（BGP） , pyridinoline （ PYD ） , estrodiol （ E2 ） and testosterone （T） level was remarkably decreased in both groups without difference between them. Conclusions GGs can inhibit the bone absorption and accelerate the osteogenesis, and are effective in osteoporosis treatment.

关 键 词：骨康冲剂 骨质疏松 临床观察 

分 类 号：R681[医药卫生—骨科学] R283.6[医药卫生—外科学]