对比重大于水的硅油/RMN3混合物作为眼内填充物的前导性研究  

A pilot study on the use of silicone oil-RMN3 as heavier than water endotamponade agent

作　　者：Rizzo S. Genovesi-Ebert F. Belting C. 陈立军 

机构地区：[1]Via Diaz 86, 55100 Lucca, Italy

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第5期37-38,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Aims: This work was conducted to report an interventional non-comparative pilot study using Oxane HD, a mixture of ultra-purified silicone oil and RMN3, a partially fluorinated olefin, as heavier-than-water internal tamponade. Methods: Twenty-eight consecutive patients were recruited for this study. Indications included recurrent retinal detachment (RD)-with proliferative vitreoretinopathy (PVR) (stage ≥C2) arising from inferior or posterior tears, recurrences after vitreoretinal surgery, penetrating trauma and combined rhegmatogenous and choroidal detachment. The patients underwent a pars plana vitrectomy, membrane peeling, and Oxane HD was used as long-term internal tamponade. Results: Oxane was removed after 88 days (range 45-96 days) and exchanged with BSS in five eyes, long-acting gas in 14 eyes and with silicone oil in nine eyes. Retinal reattachment was achieved in 15 eyes. The overall anatomical success rate obtained using Oxane HD was 53.5%. In 15 patients with previous marked scleral buckling, the success rate was 26%: in nine patients recurrent RD occurred in the inferior sector, in five patients new tears were detected in the lower sectors; membrane formation was observed in 15 eyes. In 13 patients without marked scleral indent, the success rate was 84.6%. There was no evidence of dispersion and excessive inflammation. Conclusion: Oxane HD may be a useful tool in complicated RD with large inferior breaks, inferior PVR or combined rhegmatogenous, and choroidal detachment without marked scleral buckling, which put the eye profile out of shape, led to a higher failure rate and reduced the tamponading effectiveness of Oxane HD.Aims： Thiswork was conducted to report an interventional non-comparative pilot study using Oxane HD, a mixture of ultra-purified silicone oil and RMN3, a partially fluorinated olefin, as heavier-than-water internal tamponade. Methods： Twenty-eight consecutive patients were recruited for this study. Indications included recurrent retinal detachment （RD） - with proliferative vitreoretinopathy （PVR） （stage ≥ C2） arising from inferior or posterior tears, recurrences after vitreoretinal surgery, penetrating trauma and combined rhegmatogenous and choroidal detachment. The patients underwent a pars plans vitrectomy, membrane peeling, and Oxane HD was used as long-term internal tamponade. Results： Oxane was removed after 88 days （range 45 - 96 days） and. exchanged with BSS in five eyes, long-acting gas in 14 eyes and with silicone oil in nine eyes. Retinal reattachment was achieved in 15 eyes.

关 键 词：眼内填充物 混合物 增殖性玻璃体视网膜病变 硅油 比重 复发性视网膜脱离 孔源性视网膜脱离 睫状体平坦部 水 后极部裂孔 

分 类 号：R473.77[医药卫生—护理学] R114[医药卫生—临床医学]