踏车运动较潘生丁负荷^(13)N-氨PET检查可引起更严重的心肌灌注缺损  

Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography

作　　者：Chow B.J.W Beanlands R.S Lee A. 赵君 

机构地区：[1]University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ont. K1Y 4W7, Canada,Dr.

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2006年第5期51-51,共1页

摘　　要：OBJECTIVES: The aim of this study was to compare treadmill exercise(TEX) and dipyridamole stress on the uptake and retention of N-13 ammonia. BACKGROUND: Size and severity of stress-induced myocardial perfusion defects are clinically important. Because ammonia uptake and retention seems to be related to perfusion, viability, and metabolism, exercise stress might induce larger perfusion defects than dipyridamole stress. METHODS: Twenty-six patients underwent TEX and dipyridamole stress N-13 ammonia positron emission tomography(PET). Images were assessed with a 17-segment model and a five-point score. Summed stress score(SSS), summed rest score(SRS), and summed difference score(SDS) were calculated. Left ventricular(LV) defect sizes were measured quantitatively with a 70% threshold for abnormal perfusion. RESULTS: Compared with dipyridamole stress, TEX yielded larger SSS(9.1± 5.7 vs. 6.9± 5.9; p < 0.01), SDS(5.8± 4.7 vs. 3.7± 4.6; p < 0.02), and percentage of LV stress defect(19.3± 11.5% vs. 13.8± 13.6% ; p < 0.02). CONCLUSIONS: In patients achieving adequate exercise, TEX N-13 ammonia PET myocardial perfusion imaging(MPI) yields larger stress perfusion defects than dipyridamole stress and might reflect the true myocardial ischemic burden. Treadmill exercise might be the preferred method of stress for routine N 13 ammonia PET MPI.OBJECTIVES： The aim of this study was to compare treadmill exercise（TEX） and dipyridamole stress on the uptake and retention of N-13 ammonia. BACKGROUND：Size and severity of stress-induced myocardial perfusion defects are clinically important. Because ammonia uptake and retention seems to be related to perfusion, viability, and metabolism, exercise stress might induce larger perfusion defects than dipyridamole stress. METHODS： Twenty-six patients underwent TEX and dipyridamole stress N-13 ammonia positron emission tomography（PET） .

关 键 词：潘生丁负荷 心肌摄取 灌注缺损 PET检查 踏车运动 正电子发射断层扫描(PET) 氨 心肌血流灌注 静息状态 评分法 

分 类 号：R541.404[医药卫生—心血管疾病] R817[医药卫生—内科学]