上海汉族人群维生素D结合蛋白基因多态性与2型糖尿病的相关分析  

Correlation between polymorphism of vitamin D binding protein gene and type 2 diabetes mellitus in Han people of Shanghai

作　　者：王艳波[1] 于永春[1] 李智[1] 李晶华[1] 汪纯[1] 王红玲[1] 

机构地区：[1]同济大学附属第十人民医院中心实验室,上海200072

出　　处：《中华内分泌代谢杂志》2006年第3期263-264,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(30270632)

摘　　要：采用PCR-RFLP技术研究维生素D结合蛋白(DBP)基因Asp416Glu和Thr420Lys多态性与2型糖尿病的关系。经传递不平衡检验和同胞传递不平衡检验,结果不支持连锁。但此基因多态性对胰岛B细胞功能有一定作用。PCR-RFLP method was used to analyze the correlation between Asp416Glu and Thr420Lys of vitamin D binding protein （DBP） gene and type 2 diabetes. The results showed that the two variations of DBP gene were not in linkage with type 2 diabetes via transmission-disequilibrium test and sib transmission-disequilibrium test. However, polymorphism of DBP gene might affect the function of pancreatic β cells.

关 键 词：糖尿病 2型 多态性 单核苷酸 维生素D结合蛋白基因 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]