NF-kB抑制剂对胰岛素抵抗大鼠抵抗素、脂联素和脂联素受体表达的影响  

Effect of NF-kB inhibitor on expressions of resistin,adiponectin and adiponectin receptor in Wistar rats with high fat-induced insulin resistance

作　　者：李春霖[1] 肖彧君[2] 龚燕平[1] 田慧[1] 陆菊明[2] 母义明[2] 李明[2] 潘长玉[2] 

机构地区：[1]解放军总医院老年内分泌科,北京100853 [2]解放军总医院内分泌科,北京100853

出　　处：《中华内分泌代谢杂志》2006年第3期277-278,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：十五全军医药卫生科研基金重点课题(010Z033)

摘　　要：高脂喂养大鼠脂肪组织抵抗素、脂联素的表达均明显下降,加入N-乙酰半胱氨酸后脂联素表达增高,脂联素受体1表达无改变。抵抗素和脂联素水平的降低是高脂饲养大鼠体重增加、血糖升高、脂质代谢紊乱和胰岛素抵抗的重要原因。NF-kB通路介导了脂联素对胰岛素敏感性的调节作用,但不影响脂联素受体1的表达。The expressions of adiponeetin and resistin decreased markedly in rats fed with high fat, but after N-acetylcysteine （NAC） treatment, the expression of adiponectin increased significantly （P 〈 0.01 ）. No change could be oberserved in adiponectin receptor-Ⅰ after using NAC, The decreased expressions of adiponectin and resistin might play an important role in weight gain, hyperglycemia, abnormal lipid metabolism and insulin resistance in rats fed with high fat. NF-κB inhibitor could increase adiponectin level in parallel with the improvement of high fat-induced insulin resistance, but it did not influence the expression of adiponectin receptor- Ⅰ.

关 键 词：胰岛素抵抗 NF-ΚB抑制剂 抵抗素 脂联素 脂联素受体 大鼠 Wistar 

分 类 号：R587.1[医药卫生—内分泌]