糖尿病大鼠脑葡萄糖转运子1和3蛋白表达随血糖浓度而变化  

Expressions of glucose transporter 1 and 3 proteins are changing with blood glucose concentration in diabetic rat brain

作　　者：咸玉欣[1] 侯为开[2] 侯新国[2] 董明[2] 陈丽[2] 

机构地区：[1]青岛大学医学院附属医院感染科,266003 [2]山东大学齐鲁医院内分泌科

出　　处：《中华内分泌代谢杂志》2006年第3期281-282,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：以Wistar大鼠建立链脲佐菌素糖尿病模型,用胰岛素使其血糖控制在＜10、10～14和＞16.7mmol/L 3个不同水平,用免疫组化法检测对照组及3个糖尿病组大鼠大脑中葡萄糖转运蛋白(GLUT)1和3蛋白表达变化。结果发现慢性高血糖可引起脑内GLUT1和GLUT3蛋白表达降调节。Streptozotocin-induced diabetic model was prepared in Wistar rats and the blood glucose levels were controlled at 3 levels of 〈 10, 10-14 mmoL/L or 〉 16. 7 mmoL/L by insulin, and changes of glucose transporter （GLUT） 1 and 3 protein expressions of brain were observed in control rats and diabetic rats with different blood glucose levels by immunohistochemistry. The results showed that chronic hyperglycemia could decrease the protein expressions of GLUT 1 and GLUT 3.

关 键 词：糖尿病 单糖转运蛋白质类 免疫组织化学 

分 类 号：R587.1[医药卫生—内分泌]