2型糖尿病大鼠脂肪组织脂联素和骨骼肌组织脂联素受体R1基因表达的变化  

Changes of gene expressions of adiponectin in adipose tissue and adiponectin receptor R1 in skeletal muscle of type 2 diabetic rats

作　　者：姚辉[1] 林汉华[1] 王宏伟[1] 张龙江[1] 黄晓燕[1] 夏治[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院儿科

出　　处：《中华内分泌代谢杂志》2006年第3期284-285,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：半定量RT-PCR检测2型糖尿病大鼠模型脂肪组织脂联素及骨骼肌组织脂联素受体R1 mRNA表达。与正常大鼠比较,糖尿病大鼠骨骼肌组织脂联素受体R1基因表达无改变。糖尿病大鼠血清脂联素水平下降是由脂肪组织脂联素mRNA表达降低引起的,罗格列酮治疗可以使之改善。The mRNA levels of adiponectin in adipose tissue and adiponectin receptor R1 in skeletal muscle of type 2 diabetic rats were examined by semi-quatitative RT-PCR. The expression of adiponectin receptor R1 was not altered in the skeletal muscle of type 2 diabetic rats as compared with normal rats. The serum adiponectin level was decreased in diabetic rats due to the decline of adiponectin mRNA level in adipose tissue and rosiglitazone improved the adiponectin deficiency.

关 键 词：脂联素 脂联素受体 糖尿病 2型 罗格列酮 

分 类 号：R587.1[医药卫生—内分泌]