自发性高血压鼠脑底动脉NPY mRNA的表达及其意义  

SIGNIFICANCE AND EXPRESSION OF NPY mRNA ON CEREBRAL ARTERY IN SPONTANEOUSLY HYPERTENSIVE RATS

作　　者：林雪群[1] 戴育成[2] 祝高春[1] 万丽丹[1] 

机构地区：[1]南昌大学医学院脑血管研究所,南昌330006 [2]南昌大学医学院第二附属医院分子医学中心,南昌330006

出　　处：《神经解剖学杂志》2006年第3期347-350,共4页Chinese Journal of Neuroanatomy

基　　金：江西省自然科学(No.0440062)资助项目

摘　　要：为探讨高血压大鼠脑血管神经肽Y(neuropeptide Y,NPY)在高血压时期脑血管的神经源性调节作用及其在高血压的发生和发展中的作用,本研究应用逆转录-聚合酶链反应(RT-PCR)和免疫印迹(Western blotting)技术,检测自发性高血压大鼠脑基底动脉NPY mRNA和NPY的表达变化。结果显示:自发性高血压大鼠脑基底动脉NPY mRNA和NPY的表达均较正常血压鼠明显增加。本研究结果提示NPY在自发性高血压大鼠脑血管的神经源性调节以及在高血压的发生和发展中可能起重要作用。To investigate the effect of rieuropeptide Y （NPY） on the neurogenic regulation of cerebrovascularization and in the accurrence and development of hypertension, we used the reverse transcription polymerase chain reaction （BT-PCB） and Western blotting techniques to examine the changes of expression of NPY mRNA and NPY of basilar artery in the spontaneously hypertensive rats （SHR） , respectively. The results showed that the expression of NPY mBNA and NPY level of cerebral artery in SHR was obviously higher than that in the normal rats. The present results suggest that NPY maybe play an important role in the neurogenie regulation of cerebmvascularization and in the occurrence and development of hypertension of the SHR.

关 键 词：脑动脉 神经肽Y 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]