新生儿脐血T细胞IL－2R表达和血清sIL－2R水平的研究  

THE STUDY OF EXPRESSION OF IL-2R ON T CELLS AND LEVELS OF sIL-2R IN SERA OF FETAL BLOOD OF NEONATES

作　　者：张秋业[1] 董增义[1] 耿新杰[1] 王守亮[1] 

机构地区：[1]青岛医学院附属医院儿科,青岛医学院附属医院肿瘤生物治疗室

出　　处：《中国免疫学杂志》1996年第4期259-261,共3页Chinese Journal of Immunology

摘　　要：对新生儿脐血Ｔ细胞ＩＬ－２Ｒ表达率和血清ｓＩＬ－２Ｒ水平进行检测，结果显示：①早产儿脐血Ｔ细胞ＩＬ－２Ｒ自然表达率明显低于足月新生儿和正常儿童组，而后两者间无差异；②经ＰＨＡ活化后足月新生儿和早产儿Ｔ细胞ＩＬ－２Ｒ表达率皆显著低于正常儿童组，早产儿组也明显低于足月新生儿组；③足月新生儿和早产儿脐血血清ｓＩＬ－２Ｒ水平均明显高于正常儿童组，但前两者间无明显差异；④新生儿组（包括足月和早产儿）脐血Ｔ细胞ＩＬ－２Ｒ自然表达率与血清ｓＩＬ－２Ｒ水平呈直线负相关，而正常儿童组二者间呈直线正相关。The expression rates of IL-2R on T cells and sIL-2R levels in sera of fetal blood from 37 neonates were determined. The results indicated that: ①Nature expression rates of IL-2R on T cells in fetal blood of premature infants were significantly lower than these of full-term infants and normal children, but there were no difference between full-term infant group and normal children group. ②The expression rates of IL-2R on T cells in fetal blood of full-term and premature infants at activited status with PHA were all significantly lower than these of normal children. ③The serum sIL-2R levels in fetal blood from both full-term and premature infants were all significantly higher than these in peripheral blood of normal children,but there were no significant difference between full-term infants and premature infants. (4) There were a negative correlation between nature expression rates of IL-2R on T cells and serum sIL-2R levels in fetal blood of full-term and premature infants, but there were a positive correlation in peripheral blood of normal children.

关 键 词：脐血 新生儿 IL-2R SIL-2R 

分 类 号：R446.112[医药卫生—诊断学] R446.6[医药卫生—临床医学]