颅脑损伤后血清中sICAM-1和IL-1β含量变化的意义  

Changes of serum soluble intercellular adhesion molecule-1 and interleukin-1β in patients with traumatic brain injury

作　　者：贺崇欣[1] 李振球[2] 徐善水[2] 郑伟明[1] 诸葛启钏[1] 钟明[1] 

机构地区：[1]浙江省温州医学院附属第一医院,温州325000 [2]皖南医学院附属弋矶山医院

出　　处：《浙江创伤外科》2006年第3期194-196,共3页Zhejiang Journal of Traumatic Surgery

摘　　要：目的动态观测急性颅脑损伤患者血清中sICAM-1和IL-1β含量的变化,探讨其临床意义。方法按入院先后随机选取25例被CT证实的颅脑损伤患者,按照入院时、24、48、96小时四个时间段分别采集血标本,应用双抗体夹心酶联免疫吸附法(ELISA)测定sICAM-1和IL-1β的含量,并与对照组比较。结果颅脑损伤患者早期sICAM-1含量较对照组无变化,在48小时明显升高,并持续升高至96小时(P<0.05)。sICAM-1含量与损伤程度无关,而与预后相关。血清中IL-1β含量于入院时就有明显升高(P<0.05),IL-1β升高不仅与损伤程度有关,而且与预后也密切相关。血清中IL-1β含量与sICAM-1含量相关。结论血清中sICAM-1和IL-1β参与了颅脑后继发性脑损伤,sICAM-1和IL-1β升高反映了颅内的炎症反应。Objective To observe the changes in serum levels of sICAM-1 and IL-1β in patients with traumatic brain injury. Methods Samples of twenty-five patients of traumatic brain injury within 24 hours were randomly selected. Blood samples were taken at designated times after traumatic brain injury： on admission, at 24, 48, and 96 hours. Serum levels of sICAM-1 and IL-1β were measured by enzyme linked immunosorbent assay （ELISA）. Results Mean serum concentrations of sICAM-1 in injured patient were similar to those in controls on admission and at 24 hours, but they increased significantly compared with controls at 48 hours after injury （P〈0.05）. There were no relation between serum sICAM-1 and GCS scores. Serum concentrations of IL-1β increased significantly compared with controls on admission, then reached the peak at 24 hours and sustained by 96 hours. There were negative relation among sICAM-1, GCS and GOS scores. In addition a positive correlation between sICAM-1 and IL-1β concentrations were found. Conclusion slCAM-1 and IL-1β possibly play a role in the secondary brain injury after TBI. The increases in slCAM-1 and IL-1β reflected an endogenous neuroinflammatory response.

关 键 词：颅脑损伤 可溶性细胞间粘附分子-1 白介素-1Β 

分 类 号：R541.4[医药卫生—心血管疾病] R651.15[医药卫生—内科学]