白癜风中医证型与HLA-DQB1的相关性研究  

Correlation study between syndrome type of traditional Chinese medicine of vitiligo and HLA-DQB1 alleles

作　　者：卢良君[1] 许爱娥[1] 李永伟[1] 尉晓东[1] 陈梅花[1] 

机构地区：[1]浙江省杭州市第三人民医院,浙江杭州310009

出　　处：《现代中西医结合杂志》2006年第14期1873-1875,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨白癜风中医证型与人类白细胞抗原(HLA)-DQB1等位基因的相关性及对白癜风易感性的影响。方法收集江浙籍282例白癜风患者的临床资料,并抽取其与250例健康对照者全血作为研究标本,提取DNA,用序列特异性引物(SSP)法进行等位基因检测,对各相关指标进行统计分析。结果白癜风患者HLA-DQB1*0303的检出率明显高于对照组,白癜风风湿蕴热型进展期及久病的瘀血阻络型患者DQB1*0303阳性率显著高于对照组(P<0.05),有家族史患者HLA-DQB1*0602的阳性率与无家族史患者有显著性差异(P<0.05)。结论江浙籍汉族白癜风风湿蕴热型进展期患者及久病的瘀血阻络型患者存在较显著的白癜风易感性,HLA-DQB1*0602可能与白癜风遗传易感体质相关。Objective It is to discuss the correlation between syndrome type of traditional Chinese medicine of vitiligo and HLA-DQB1 alleles, and their effects on susceptibility of vitiligo. Methods Whole blood of 282 patients with vitiligo in Jiangzhe area and 250 healthy people were collected as specimen to extracting DNA, the alleles were detected by polymerase chain reaction （PCR） with sequence specific primers （SSP）. Statistical analysis were completed included all related factors.Results Positive rate of HLA - DQB1 ＊ 0303 was found significantly increased in vitiligo patients than that in control group. It had a significant increase in developing wind-damp-heat group and long term blood-statis group patients than control group （P 〈 0.05）. HLA - DQB1 ＊ 0602 had a significant difference between patients with family history and patients without （ P 〈 0.05）. Conclusion Of Han ethnical patients in Jianzhe China, developing wind-damp-heat patients and long term bloodstatis patients had a significantly susceptibility of vitiligo, HLA- DQB1 ＊ 0602 may be related with susceptible constitution of vitiligo.

关 键 词：白癜风 易感性 中医证型 HLA-DQB1等位基因 

分 类 号：R275.984.1[医药卫生—中西医结合]