糖尿病血管平滑肌细胞钙离子稳态调节的改变与细胞增殖  

The Regulation Changes of Calcium Homeostasis and Cell Proliferation of Diabetic Vascular Smooth Muscle Cells

作　　者：黄玉玲[1] 

机构地区：[1]中山大学中山医学院心脑血管研究中心,广州510080

出　　处：《中山大学研究生学刊（自然科学与医学版）》2006年第2期7-13,共7页Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)

摘　　要：糖尿病已成为第三大威胁人类健康的疾病。目前虽然在临床上能有效控制患者血糖水平,但是糖尿病患者最终死亡于合并症。研究表明,糖尿病可加速动脉粥样硬化,粥样斑块的平滑肌细胞显示更强的增殖能力。Ca2+作为胞内重要的信使参与细胞的许多生理活动,如细胞的增殖、凋亡等等。胞内钙离子的升高主要来源于胞外钙离子的内流与胞内钙池的释放。胞内钙池主要由IP和ryanodine两大钙池系统组成,它们共同调节着胞内钙离子运动。Diabetes Mellitus has become the third important disease which threats human＇ s health. Though, at present , we can control the high glucose level, diabetic patients still die of it＇ s complications. As indicated, diabetes mellitus may accelerate atherosclerosis and vascular smooth muscle cells in atheromatous plaque proliferate than others. Ca^2＋ which acts as the most important second messenger is involved in many physiological functions, such as cell proliferation, apoptosis and so on.. Increase of intracellular Ca^2＋ comes predominandy from Ca^2＋ influx from extracellular as well as Ca^2＋ release from intracellular calcium store. Intracellular calcium store is composed of IP3 receptor and ryanodine receptor, both of which participate in accommodating intracellular Ca^2＋ movement as well as cell proliferation.

关 键 词：糖尿病 电压依赖性钙通道 受体操纵性钙通道 钙池 细胞增殖 

分 类 号：Q253[生物学—细胞生物学] O657.31[理学—分析化学]