那格列奈的合成工艺研究  

Synthesis of Antidiabetic Drug Nateglinide

作　　者：邓燕[1] 蒋欢妹[1] 谢维跃 陶德良[1] 

机构地区：[1]湖南工业大学绿色包装与生物纳米技术应用重点实验室,湖南株洲412008 [2]湖南轻工研究院,湖南长沙410015

出　　处：《精细化工中间体》2006年第3期19-20,42,共3页Fine Chemical Intermediates

摘　　要：对那格列奈的生产工艺中的反应时间、温度、试剂的选择等进行探索、改进,选用对异丙基苯甲酸为起始原料,采用低压氢化,直接碱性转位得对异丙基环己酸,并用三氯化磷酰氯化后与苯丙氨酸甲酯缩合制得那格列奈,总收率50.76%。Nateglinide is a kind of new antidiabetic drug, which has a wide market prospect. In view of the present problems in the synthesis of nateglinide, the optimum synthesis conditions such as reaction time, temperature and reagent, etc were investigated and improved. Nateglinide was synthesized from 4-isopropylbenzonic acid as starting material through low-pressure catalytic hydrogenation, alkalescence displacement and condensation and the total yield was 50.76%.

关 键 词：那格列奈 药物 合成 

分 类 号：R977.15[医药卫生—药品]