砂仁提取物对实验性糖尿病大鼠的降血糖作用  

Hypoglycemic effects of extract of Amomum Xanthoides on experimental diabetes in rats

作　　者：赵容杰[1] 赵正林[2] 金梅红[2] 金相赞 梁在夏 

机构地区：[1]延边大学基础医学院药理学教研室,吉林延吉133000 [2]延边大学基础医学院人体解剖学与组织胚胎学教研部,吉林延吉133000 [3]大邱韩医科大学

出　　处：《延边大学医学学报》2006年第2期97-99,共3页Journal of Medical Science Yanbian University

摘　　要：[目的]探讨砂仁提取物对实验性糖尿病大鼠的降血糖作用.[方法]利用链脲佐菌素制作大鼠糖尿病动物模型,给糖尿病治疗组大鼠腹腔注射砂仁提取物20 mg每日2次,共2周,观察治疗前后血糖的变化及胰岛β细胞超微结构变化.[结果]糖尿病治疗组大鼠血糖明显降低,与糖尿病对照组比较有显著性差异;砂仁提取物对糖尿病大鼠胰岛β细胞具有明显的保护作用,并可改善胰岛β细胞超微结构变化.[结论]砂仁提取物对实验性糖尿病大鼠具有降血糖作用.OBJECTIVE To investigate the hypoglycemic effects of extract of Amomum Xanthoides on STZ-induced experimental diabetes in rats. METHODS The experimental diabetic model in rats were induced by tail vein injection of STZ（30 mg/kg）, and those in treatment group were given 20 mg of extract of Arnornurn Xanthoides for 2 weeks, then the blood glucose levels and the morphological changes in pancreatic islet β-cells were determined to evaluate the effects of extract of Amomum Xanthoides. RESULTS The blood glucose level in treatment group was decreased, and there were significantly difference compared with control group; the extract of Arnomum Xanthoides had protective effects on β-cells in pancreatic islets and improved morphology of β-cells in pancreatic islets in diabetic rats. CONCLUSION The extract of Amomum Xanthoides has hypoglycemic effects on experimental diabetes in rats.

关 键 词：糖尿病 实验性 植物 药用 大鼠 

分 类 号：R285.5[医药卫生—中药学]