某院2879株临床分离病原菌及耐药性分析  

THE ANALYSIS OF 2879 STRAINS OF PATHOGENIC BACTERIA SEPARATED IN CLINICS AND ITS DRUG RESISTANCE

作　　者：杨增茹[1] 许东风[2] 刘菲菲[3] 余雪[2] 

机构地区：[1]河南南阳医学高等专科学校微生物学与免疫学教研室,南阳473058 [2]南阳医学高等专科学校附属医院呼吸科 [3]南阳医学高等专科学校附属医院检验科

出　　处：《现代预防医学》2006年第7期1094-1096,共3页Modern Preventive Medicine

摘　　要：目的:了解临床感染性疾病中常见病原菌的种类、分布及耐药情况。方法:采用法国梅里埃全自动细菌鉴定仪VITEK2系统和传统操作两种方法对标本进行鉴定和药敏试验,传统操作法药敏试验用WHO推荐的药物纸片扩散法(K-B法),NCCLS标准判定结果。结果:从临床标本中分离细菌2 879株,其中,革兰阳性菌(G+)902株(31.3%);革兰阴性菌(G-)1 235株(42.9%)、真菌419株(14.6%);其他菌株323株(11.2%)。G+对万古霉素、丁胺卡那霉素、派拉西林/他巴坦、呋喃妥因的敏感率分别为98.0%、70.2%、50.3%、66.8%;G-对妥布霉素、丁胺卡那霉素、派拉西林/他巴坦、头孢他啶、左氧氟沙星的敏感率分别为78.1%、72.0%、68.6%、61.0%、46.2%。结论:耐药菌株及耐药率在不断增加和上升,应加强医院对细菌的监控,配合临床合理有效地应用抗菌药物,延缓耐药菌株的产生。Objective： To know the type, distrbution and drug resistance situation of common pathogenic bacteria in clinical infectious diseases. Methods： VITEK2 system of france merieus fully automatic bacteria culture analytic instrument and artificial procedure were used in monitoring the specimen and drug sensistivity test. Drug paper diffusion method （K - B） was used in artificial drug sensistivity test, which was recommended by WHO. Results was judged by using Nccls Standard. Results： 2 879 Strains of bacteria were separated from clinical samples, among which, 1 235 strains （42.9%） were Gram negative （G^-） and 902 strains were （31.3%） Gram-positive （G^＋ ）; 419 strains （14.6%） were fungus and 323 other strains （11.2%）. Drug Sensistivity rate of G^＋ to Vaneomycin, Amikacin, Piperacillin/Tazobactan and Nitrofuyntion was 98.1%, 71.4%, 68.7% and 51.0% respectively; that of G^- to tobramycin, Amikacin, Piperacillin/Tazobactan, Ceftazidime and levoflxacin was 78.1%, 72.0%, 68.6%, 61.0% and 46.2% respectively. Conclusion： Because of the increment of drug resistance rate and drug risistance strains, the monitoring to bacteria should be strengthened in order to ccoperat with clinics to use the antibiotic reasonably and delay the production of drug resistance strains.

关 键 词：病原菌 耐药性 抗菌药物 

分 类 号：R37[医药卫生—病原生物学]