维生素E对大鼠血液铁状态和脑铁代谢的影响  

Effects of vitamin E on hematological iron status and non-heme iron content in rat

作　　者：肖德生[1] 刘淑杰[1] 蒋璐[1] 车力龙[1] 钱海[1] 曹惠芝[1] 

机构地区：[1]江苏大学医学院,江苏镇江212001

出　　处：《江苏大学学报（医学版）》2006年第3期216-218,221,共4页Journal of Jiangsu University：Medicine Edition

基　　金：国家自然科学基金资助项目(30270639);江苏省社会发展计划项目(BS2003022);江苏大学研究基金资助项目(02JDG028)

摘　　要：目的:观察不同含量维生素E(VE)膳食对大鼠血液铁状态和脑铁贮存的影响。方法:雌性SD大鼠随机分为3组:VE缺乏组(LVE),正常含量VE组(NVE),补充VE组(HVE)。喂养3个月后断头取血和脑组织,测定血液铁状态指标和各脑区非血红素铁(NH I)含量。结果:与NVE组相比,LVE组血红蛋白(Hb)浓度显著升高,总铁结合力(TIBC)显著增大,血浆铁浓度(PI)没有显著变化;HVE组Hb没有显著变化,但TIBC降低,PI升高,导致血浆铁饱和度升高。与NVE组相比,LVE组和HVE组下丘脑的NH I均显著降低,延髓NH I均显著升高,HVE组中脑的NH I显著升高,但LVE组没有显著变化,在两组其他脑区NH I含量均未发现显著变化。结论:膳食VE含量变化可改变血液铁状态和脑内铁稳态。Objective： This study was to observe the effects of variations of dietary vitamin E （VE） on hematological iron status and non-heine iron content in rat. Methods： Female Sprague-Dawley rats were randomly assigned to three groups according to levels of dietary vitamin E, including low VE diet （ LVE）, normal VE diet （ NVE）, and high VE diet （HVE）. The hematological indices of iron status and the nonheme iron of brain were determined at the end of the three months. Results： As compared with the NVE, LVE had its significantly higher hemoglobin （Hb） concentration and total iron binding capacity （ TIBC ） without significant changes in plasma iron concentration （PI） ;HVE had a significantly lower TIBC with a significant increase in PI and transferrin iron saturation. On the other hand, as compared with the NVE, both LVE and HVE had their significantly lower NHI in the hypothalamus and their significantly higher NHI in the medulla oblongata, and no significant changes were found in the other brain regions. Conclusion： Variations of dietary vitamin E may influence the hematological iron status and brain iron metabolism.

关 键 词：脑 铁 维生素E 

分 类 号：G804.7[文化科学—运动人体科学]