不同糖耐量原发性高血压患者血清游离脂肪酸成分变化特征研究  

Study on Serum Free Fatty Acid Profile in Patients with Essential Hypertension Accompanying Different Glucose Tolerance

作　　者：李嘉强[1] 戴颖秀 刘玉敏[2] 郑基 刘文斌 

机构地区：[1]上海市杨浦区疾病预防控制中心,200090 [2]上海交通大学分析测试中心 [3]上海市杨浦区平凉社区卫生服务中心 [4]上海市杨浦区五角场社区卫生服务中心

出　　处：《中国预防医学杂志》2006年第3期170-173,共4页Chinese Preventive Medicine

基　　金：上海市杨浦区卫生局科研基金资助(2002AA001-005)

摘　　要：目的研究不同糖耐量原发性高血压患者血清游离脂肪酸(FFA)成分变化特征及其与血糖参数间关系。方法用气相色谱/质谱(GC/MS)联用法测定122例不同糖耐量原发性高血压患者与43例正常对照组血FFA成分水平。结果原发性高血压组不饱和脂肪酸(C18∶2、C18∶1、C20∶4、C22∶6、C20∶3)高于正常对照组,在C18∶2、C20∶3间差异有统计学意义(P<0.01);不饱和脂肪酸/总脂肪酸(UFA/TFA)、多不饱和脂肪酸/总脂肪酸(PUFA/TFA)、多不饱和脂肪酸/饱和脂肪酸(PUFA/SFA)显著高于正常对照(P<0.01);饱和脂肪酸(C16∶0、C18∶0)和饱和脂肪酸/总脂肪酸(SFA/TFA)低于正常对照组,差异有统计学意义(P<0.01,P<0.05)。伴有糖尿病亚组与单纯高血压糖耐量正常亚组相比,亚油酸(C18∶2)、n6/n3升高,C20∶5、C18∶3下降,差异有统计学意义(P<0.05);两者饱和脂肪酸(C16∶0、C18∶0)、UFA/TFA、PUFA/TFA、PUFA/SFA、SFA/TFA间均无统计学意义(P>0.05)。在研究对象中,血糖与UFA/TFA、PUFA/TFA、PUFA/SFA呈正相关(r=0.244,0.219,0.242,P<0.01),与SFA/TFA呈负相关(r=-0.244,P<0.01)。结论原发性高血压患者中存在游离脂肪酸代谢紊乱。n6系多不饱和脂肪酸升高,可能在原发性高血压、特别是在伴有糖代谢异常的高血压发病中起重要作用。调整膳食结构,可以减少脂质过氧化损伤。Objective To explore the relationship between serum free fatty acid （FFA） profile and fasting blood glucose （FBG） in patients with essential hypertension （EHp） accompanying different glucose tolerance. Methods The FFA profile was measured with the gas chromatography and mass spectrometer （GC/MS） in 122 patients and 43 control subjects. Results qlae patients with EHp had higher parameters of unsaturated fatty acid （UFA, C18：2, C18：1. C20：4, C22：6, C20：3）, and polytmsaturated fatty acid （PUFA, C18：2, C20：3）. UFA/TFA, PUFA/TFA and PUFA/SFA showed a significant increase as compared with those in the normal subjects （ P 〈0.01） .Saturated fatty acid （SFA, C16：0, C18：0） and SFA/TFA in patients with EHp were decreased remarkably than that in the healthy controls （ P 〈 0.01, P 〈 0.05） .EHp with diabetes had increased linoleic acid （C18：2）, n6/n3 and decreased C20：5, C18：3 compared to the EHp accompanying normal glucose tolerance （P 〈 0.05） .Both of them had no significant difference above mentioned SFA （C16：0, C18：0）, UFA/TFA, PUFA/TFA, PUFA/SFA, SFA/TFA （P〉O.05） .FBG had remarkably positive correlation with UFA/TFA, PUFA/TFA and PUFA/SFA （ r = 0.244, 0.219, 0.242, P 〈 0.01, respectively） and a negative correlation with SFA/TFA （r= -0.244, P〈0.01） in these all subjects. Conclusion Tnisstudysurgeststhat there was the FFA metabolic abnormality in patients with EHp. Increased levels of n6PUFA may play a role in the pathogenesis of EHp and EHp with glucose metabolic abnormality especially. Balanced dietary may improve upon the increased lipid peroxidation.

关 键 词：原发性高血压 游离脂肪酸谱 气相色谱/质谱联用技术 

分 类 号：R544.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]