章丘市埃可病毒30型致无菌性脑膜炎暴发后健康儿童血清流行病学分析  

Comparative Analysis on Seroepidemiology of An Aseptic Meningitis Outbreak Under 15 Years Old Children Caused by ECHO_(30) One Year Later

作　　者：董微[1] 张济[1] 赵小东[1] 胡艳霞[1] 刘翀[1] 周志中[1] 杨华[1] 韩晓辉[1] 

机构地区：[1]济南市疾病预防控制中心,山东250013

出　　处：《中国预防医学杂志》2006年第3期188-191,共4页Chinese Preventive Medicine

摘　　要：目的 了解章丘市ECH030型致无菌性脑膜炎暴发1年后≤15岁健康儿童埃可病毒30型（ECH030）的人群感染情况。方法中和抗体检测技术测定血清抗体水平。结果章丘市存在ECH030所致无菌性脑膜炎的暴发，≤15岁健康人群中和抗体几何平均滴度（GMT）为1：53．08，显著高于非流行区的GMT（1：32．45）。流行区中和抗体滴度集中分布在1：64—1：256（36．52％），年龄别抗体水平有差异，≥3岁人群随着年龄的增长，抗体水平呈下降趋势。非流行区人群血清中和抗体水平无年龄别差异。结论ECH030所致疾病流行后，人群具有一定的免疫力；非流行区未出现该毒株所致疾病的流行。Objective To precisely describe the infection status of ECHO30 in healthy children under 15 years old in Jinan, especially in Zhangqiu City. Method To test the level of sera neutralization antibody depends on the technology of enutralization test. Results An outbreak of aseptic meningitis caused by ECHO30 existed in Zhangqiu City, and the type specific neutralizing antibody titer of epidemic area was higher than that of non - epidemic area in children under 15 years old, geometric mean fiter （GMT） were 1：53.08 and 1：32.45, respectively, the antibody titer distribution of case group concentrate from 1：64 - 1：256, and there was divergence among the age specific groups, the antibody titers descended with the up of age specific groups upwards of 3 years old group in case group. There was no divergence of antibody titers among the age specific groups in non - epidemic area, similarly to the sex specific groups. Conelusios It showed that population immunity was elevated after art epidemic of infectious disease, and there was no epi- demic of that disease caused by ECHO30 in non- epidemic areas.

关 键 词：埃可病毒30型 无菌性脑膜炎 血清流行病学 分析 

分 类 号：R181.3[医药卫生—流行病学]