缓释异搏定与尼群地平治疗高血压性左心室肥厚的疗效比较  

Effects of slow-releaxing Verapamin on the Hypertensive Hypertrophy of Left Ventricle of Heart as Compared with Nitredipine

作　　者：汪碧衡[1] 廖文富[1] 孙明 

机构地区：[1]湖南师范大学医院内科,衡阳医学院附属第一医院内科,湖南医科大学湘雅医院心内科

出　　处：《中国动脉硬化杂志》1996年第2期128-130,共3页Chinese Journal of Arteriosclerosis

摘　　要：按照随机和单盲法，将５４例原发性高血压左心室肥厚患者分为缓释异搏定组和尼群地平组，治疗前后进行血压、心率、心功能及左心室肥厚测定。结果发现，治疗１６周后两组患者血压均明显降低，与治疗前相比较，差异有显著性意义（Ｐ＜０．０１）。缓释异搏定组患者心率下降（Ｐ＜０．０１），左心室舒张功能明显改善（Ｐ＜０．０１），肥厚的左心室逆转（Ｐ＜０．０５）；尼群地平组患者心率、心功能和左心室肥厚均无明显改变（Ｐ＞０．０５）。Fifty-four cases with primary hyperten sive hypertrophy of left ventricle were randomly divided into two groups,one treated with slow-releaxing vera pamin,the other with nitredipine,The blood pressure,heart rate,cardiac function and thickness of left ventri cle were measured before and after treatment in both groups.In the group treated with slow-releaxing vera pamin,the blood pressure declined very significantly(P<0.01) ,heart rate declined (P<0.01),function of left ventricle improved (P<0.01)and hypertrophy of left ventricle reversed favourably(P<0.05).On the contrary only the blood pressure declined(P<0.01) and there were nothing improving in the other aspects in group treated with nitredipine (P>0.05).

关 键 词：高血压 左心室肥厚 缓释异博定 尼群地平 

分 类 号：R544.105[医药卫生—心血管疾病] R972.4[医药卫生—内科学]