肾移植组织配型管理软件的研究与开发思路(英文)  

Application of the fast HLA matching software for organ transplantation

作　　者：张治国[1] 郑丽[1] 叶启发[1] 夏穗生[1] 

机构地区：[1]中南大学湘雅三院器官移植中心,湖南长沙430013

出　　处：《中国医学工程》2006年第3期225-227,共3页China Medical Engineering

摘　　要：目的开发肾移植组织配型管理软件并观察其临床实用性。方法参考氨基酸残基配型及致敏性错配制定配型标准,采用Powerbuild系统编制同种异体肾移植组织配型管理软件,观察肾移植术前快速组织配型分析的可行性。结果从筛选最佳供受者到列表打印结果仅需数分钟,历史数据可查询,界面简单,结果准确、可靠。配型标准可自行更改。结论经国内8家移植中心使用,证明该软件设计科学合理,操作简便,运行稳定,实用性强,具有一定的推广价值。[Objective] To devise a fast HLA matching software used for organ transplantation and evaluate the application to HLA compatibility in the clinical transplant works. [Methods] The software was designed with Powerbuild system, in which the reference standard of HLA matching was that of GREG and immunogenic antigen locas. With the software the feasibility used for clinical works had been observed. [Result] Only several minutes were needed to choice the donor and the recipients who had best HLA matching. Doctors might obtain a report which included full data in HLA matching. The history datum might be inquired, the interface of the software was simple and the results was credible. Matching criterion of the software is renewable by oneself. [Conclusion] The software has been used in eight branches of the transplant centers in china and proved to be designed scientifically, operated simply and stably. It deserves to be popularized in transplant departments.

关 键 词：HLA配型 交叉反应组 免疫原性错配 肾移植 程序 

分 类 号：R692[医药卫生—泌尿科学]