新型DNA分子光开关钌(Ⅱ)配合物的研究  

A Novel Ru(Ⅱ) Complex Based DNA Molecular Light Switch

作　　者：郝强[1] 段智明[1] 韩美娇[1] 郑帅至[1] 吕媛媛[1] 王科志[1] 

机构地区：[1]北京师范大学化学院,北京100875

出　　处：《高等学校化学学报》2006年第7期1217-1219,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20371008;90401007)资助

摘　　要：A new ruthenium（Ⅱ） complex,[Ru（bpy）2bdpq](ClO4)2,where bpy=2,2′-bipyridine,（bdpq=2-（benzoxazol-2-yl）-dipyrido） [2,3-f: 2′,3′-h]quinoxaline,was synthesized and characterized by IR,（）1H NMR,MALDI-TOF MS,and elemental analysis.The electronic absorption and emission spectral titrations with calf thymus DNA,steady-state emission quenching by [Fe（CN）6]4-,and viscosity measurements were carried out to study the binding of [Ru（bpy）2bdpq](ClO4)2 with the DNA.The results indicate that the（Ru（Ⅱ）） complex acts as a DNA intercalator with a binding constant of（1.9±0.1）×106 L/mol at 50 mmol/L NaCl,and can serve as a good "DNA molecular light switches" with a luminescence enhancement factor of 180.A new ruthenium （Ⅱ） complex, [Ru （bpy） 2 bdpq] （ClO4） 2, where bpy = 2,2＇-bipyridine, bdpq = 2-（benzoxazol-2-yl）-dipyrido [2,3-f： 2＇ ,3＇-h] quinoxaline, was synthesized and characterized by IR, 1^H NMR, MALDI-TOF MS, and elemental analysis. The electronic absorption and emission spectral titrations with calf thymus DNA, steady-state emission quenching by [ Fe（ CN）6 ]^4-, and viscosity measurements were carried out to study the binding of [ Ru （bpy） 2 bdpq ] （CIO4） 2 with the DNA. The results indicate that the Ru（Ⅱ） complex acts as a DNA intercalator with a binding constant of （1.9 ＋0. 1） ×10^6 L/mol at 50 mmol/ L NaCI, and can serve as a good ＂DNA molecular light switches＂ with a luminescence enhancement factor of 180.

关 键 词：钌(Ⅱ)配合物 插入键合 光开关 

分 类 号：O614[理学—无机化学] O641.821[理学—化学]