Corrole光敏剂在光动力治疗中的重原子效应  

Heavy-atom Effect of Corrole Photosensitizer for Photodynamic Therapy

作　　者：刘海洋[1] 郭平叶[1] 江柏荣[2] 应晓[3] 廖世军[1] 麦乃歧[4] 张启光[2] 

机构地区：[1]华南理工大学化学系,广州510641 [2]香港科技大学化学系 [3]华南理工大学应用物理系,广州510641 [4]香港浸会大学生物系

出　　处：《高等学校化学学报》2006年第7期1363-1365,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20476034);香港研究资助局项目(批准号:CA03/04SC01;HKBU2052/02M);教育部留学回国人员科研启动基金(批准号:2004527)资助

摘　　要：10-(2-Hydroxylphenyl)-5,15-bis(pentafluorophenyl) corrole([STHZ]1) was found to have a remarkable photocytotoxicity on nasopharyngeal carcinoma(NPC) cell line(Chang C.K.et al.,Proc SPIE,2006,Vol.6139,p268).To explore the heavy-atom effect on corrole photosensitizer,an exact analogue of corole [STHZ]1[STBZ] with the modification of two heavy iodine atoms on its 10-phenyl group,10-(2-hydroxyl-3,5-diiodophenyl)-5,15-bis(pentafluorophenyl)corrole(2),were synthesized.Surprisingly,the photocytoxicity of corrole 2 on NPC cell dropped sharply as compared to corole 1.It exhibited no significant PDT cytotoxicity even if its concentration reached 2 μmol/L.This may be caused by the lowering of its singlet oxygen quantum yield in PDT, although the intersystem crossing of corrole 2 could be enhanced by iodine heavy-atom effect as indicated by the strong decrease of its fluorescence emission.10-（2-Hydroxylphenyl）-5,15-bis（pentafluorophenyl） corrole（1） was found to have a remarkable photocytotoxicity on nasopharyngeal carcinoma（NPC） cell line（ Chang C. K. et al. , Proc SPIE, 2006, Vol. 6139, p268）. To explore the heavy-atom effect on corrole photosensitizer, an exact analogue of corole 1 with the modification of two heavy iodine atoms on its 10-phenyl group, 10-（2-hydroxyl-3,5-diiodophenyl）-5,15- bis（pentafluorophenyl） corrole（2）, were synthesized. Surprisingly, the photocytoxicity of corrole 2 on NPC cell dropped sharply as compared to corole 1. It exhibited no significant PDT cytotoxicity even if its concentration reached 2 μmol/L. This may be caused by the lowering of its singlet oxygen quantum yield in PDT, although the intersystem crossing of corrole 2 could be enhanced by iodine heavy-atom effect as indicated by the strong decrease of its fluorescence emission.

关 键 词：CORROLE 光敏剂 鼻咽癌 光动力治疗 重原子效应 

分 类 号：O644.12[理学—物理化学]