uPA系统在子宫内膜异位症中的表达及意义  

Expression and significance of uPA,uPAR,PAI-1 in endometriosis.

作　　者：陈华清[1] 何福仙[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《现代妇产科进展》2006年第5期350-352,355,i0001,共5页Progress in Obstetrics and Gynecology

摘　　要：目的:研究尿激酶型纤溶酶原激活剂(uPA)及其受体(uPAR)和纤溶酶原激活剂抑制剂(PAI-1)在子宫内膜异位症中的表达和意义。方法:采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接法(S-P法)分别检测30例子宫内膜异位症患者的异位内膜及其相应的在位内膜(研究组)以及30例正常子宫内膜(对照组)中uPA、uPAR、PAI-1的表达。结果:异位内膜和在位内膜及对照组子宫内膜组织中,uPA的表达分别为0.198、0.112、0.079;uPAR的表达分别为0.162、0.119、0.076;PAI-1的表达分别为0.230、0.158、0.080;异位内膜组织中uPA、uPAR、PAI-1与在位内膜及对照组相比,差异均有统计学意义(P<0.05,P<0.01);在位内膜组织中uPA、uPAR、PAI-1与对照组比较,差异亦有统计学意义(P<0.05)。无论是增殖期还是分泌期,异位内膜组织中uPA、uPAR、PAI-1的表达均高于在位内膜及对照组(P<0.05,P<0.01),在位内膜中uPA、uPAR、PAI-1的表达高于对照组(P<0.05)。结论:异位和在位子宫内膜组织中uPA、uPAR、PAI-1表达的变化可能与子宫内膜异位症的发生、发展有关。Objective：To study the clinical significance and expression of uPA,uPAR, PAI-1 in endometriosis. Methods： The expression of uPA, uPAR, PAI-1 in the ectopic and eutopic endometrium were detected by immunohistochemistry streptavidin-biotin peroxidase（S-P） method in 30 patients with endometriosis and in 30 normal women. Results：In the ectopic and eutopic endometrium with endometriosis and in the normal endometrium, the expression of uPA was 0. 198,0. 112 and 0. 079 respectively; the expression of uPAR was 0. 162,0. 119 and 0. 076 respectively ; the expression of PAI-1 was 0. 230,0. 158 and 0. 080 respectively. The difference of uPA, uPAR, PAI-1 in the ectoplc endometnum anti in the eutopic endometroum and the normal endometrium was markedly significant（P 〈 0.05 or P 〈 0.01 ）. The difference of the expression of uPA.uPAR.PAI-1 between ectopic and the eutopic endometrium was also markedly significant（P 〈 0.05）. In the whole menstrual period,the expression levels of uPA, uPAR, PAI-1 in the ectopic endometrium was higher than those in the eutopic endometrium with endometriosis and the normal endometrium （ P 〈 0.05 or P 〈 0. 01 ）. Expression of uPA, uPAR, PAI-1 in the eutopic endometrium was also higher than that in the normal endometrium （P 〈 0.05 ）. Conclusion： The change of expression uPA, uPAR, PAI-1 in ectopic and eutopic endometrium may be related to the pathogenesis of endometriosis.

关 键 词：子宫内膜异位症 尿激酶型纤溶酶原激活剂及其受体 纤溶酶原激活物抑制物 

分 类 号：R711.71[医药卫生—妇产科学]