日本血吸虫病流行区HBV与血吸虫感染相关性血清流行病学调查  

The seroepidemiological survey on the relationship between HBV and schistosome infection in an endemic area of schisomiasis japonica

作　　者：汪奇志[1] 姜庆五[1] 汪峰峰[2] 尹晓梅[2] 强广翔 邓乐军 张功华[2] 方国仁[2] 汪天平[2] 肖祥[2] 

机构地区：[1]复旦大学公共卫生学院流行病学教研室,上海200032 [2]安徽省血吸虫病防治研究所 [3]南陵县血吸虫病防治站

出　　处：《中国病原生物学杂志》2006年第3期177-180,共4页Journal of Pathogen Biology

基　　金：国家十五科技攻关计划项目(No.2004BA718B05);安徽省"十五"二期传染病综合防治研究专项(No.040130326)

摘　　要：目的 了解血吸虫病流行区HBsAg人群分布规律及其与血吸虫感染的相关性。方法 在安徽省一中度血吸虫病流行村，采用病原学方法（Kato-Katz法，二送六检）和血清学方法（ELISA法、IHA法串联筛检方案）进行血吸虫感染情况检测，同时平行检测HBsAg（ELISA法），并进行相关个案调查。结果 1）居民HBsAg阳性率11．21％（105／937），其中男性12．38％（50／404），女性10．32％（55／533），性别间差异无显著性（wald=1．545，P=0．214）；25-34岁及以上年龄组HBV感染的危险度（OR）是5～14岁组的8．852～10．5ll倍（P均d0．001）；2）血吸虫抗体阳性率与HBsAg携带率年龄性别分布曲线走向基本一致，有随年龄增大而上升趋势；≥25岁居民血吸虫抗体阳性率、粪检阳性率、HBsAg携带率分别在30％、3．13％和10％以上；3）慢性血吸虫病患者与非血吸虫病患者HBsAg携带率分别为7．69％和9．96％，HBsAg平均A值分别为0．180（一0．005，0．364）和0．234（0，141，0．327），差异无显著性（P均〉0．05）。血吸虫抗体阳性与阴性者HBsAg携带率分别为12．26％、10．66％，HBsAg平均A值分别为0，246（0，166，0．327）和0．241（O．182，0．301），差异无显著性（P均〉0．05）。结论 本研究未发现HBV与血吸虫感染有相关性，但≥25岁居民血吸虫合并HBV感染的潜在威胁不能忽视。Objective To understand the prevalence of hepatitis B virus （HBV） in an endemic area of shistosomiasis ja- ponica and its correlation with Schistosoma japonicum infection. Methods A populationK-based survey was carried out in an endemic village of schistosomiasis japonica, with the estimated infection rate of above 5 %. Kato-Katz and serological （ELISA in series with IHA） techniques were used to detect the infection of S. japonicum, and ELISA tested for HBsAg, simultaneously. Results 1） In the village, the total positive rate of HBsAg was 11.21%（105/937）. The results of non-conditional logistic regression showed that the HBsAg carriage rate of the male [12.38% （50/404）] was not statisti- cally significant higher than the female [10.32%（55/533）] （P〉0.05）, and the residents aged above 25 years had a high- er risk of HBV infection compared with those aged 5-14 years （OR=8. 852--10. 511） （P〉0.05） ; 2）Both the age-spec- ified positive rate of anti-SEA-Ab and HBsAg increased along with age in the population, especially, for aged above 25 years, the positive rates of anti-SEA-Ab and HBsAg as well as schistosome eggs remained higher level （30%, 10%, 3.13%, respectively）; 3） The carrier rate and the average A value（ELISA） of HBsAg in the chronic schistosomiasis pa- tients was 7.69 %, 0.180 （- 0. 005,0. 364）, respectively, both of which was no statistically significant difference with the non-schistosomiasis residents[9.96% ,0. 234（0. 141,0. 327）]. Similarly, both of the carriage rate and the average A value of HBsAg of anti-SEA-Ab positive subjects [12.26%, 0. 246（0. 166,0. 327）] were not significantly higher than the anti- SEA-Ab negative ones [10.66% ,0. 241（0. 182,0. 301）] Conclusion The population-based survey do not demonstrate the infection correlation of HBV with schistosome. However, it should not be ignored that there exists latent hazard re- sulted from a high probability of combined infection of schistosome and HBV in the local residents, esp

关 键 词：血吸虫病 乙肝病毒 血清学 相关性 

分 类 号：R373.2[医药卫生—病原生物学] R383.24[医药卫生—基础医学]