清开灵对戊四氮致大鼠海马神经肽Y变化的影响  

Effect of Qingkailing on Distribution and Level of Neuropeptide Y in Brain of Epileptic Rats

作　　者：田野[1] 唐洪丽[1] 王晨虎[1] 黄秋玲[1] 

机构地区：[1]东南大学附属中大医院儿科,南京210009

出　　处：《实用儿科临床杂志》2006年第12期739-740,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的研究大鼠海马部位神经肽Y(NPY)的分布和水平,及清开灵干预治疗作用。方法采用戊四氮(PTZ)制备大鼠癫模型。放射免疫法和免疫组织化学测定大脑海马组织匀浆NPY水平。结果免疫组织化学显示点燃模型组阳性反应神经元增多,清开灵干预组阳性反应神经元则明显增多。点燃模型组海马组织匀浆NPY的放射免疫测定浓度增高(P<0.05);清开灵干预组海马组织匀浆NPY的放射免疫水平与点燃模型组相比明显升高(P<0.05)。结论NPY参与癫的发病过程。清开灵注射液通过增加海马组织NPY水平,可能成为治疗癫的重要药物。Objective To explore the effect of Qingkailing on the distribution and contents of neuropeptid Y（NPY） in hippocampus of epileptic rats. Methods Adopt abdominal cavity injection pentetrazole was used to establish the model of epileptic rats. Then content of NPY was assayed by radio - immunity and the distribution was observed by immunohistochemistry. Results The content of NPY in kindling group was significantly higher than that in control group（ P 〈 0.05 ）;The content of NPY in Qingkailing group was significantly higher than that in kindling group（P 〈 0.05）. Conclusions NPY plays an important role in epilepsy. Qingkailing may be a new way to treat epilepsy.

关 键 词：癫痫 点燃效应 戊四氮 神经肽Y 清开灵 

分 类 号：R285.5[医药卫生—中药学]