非感染性疾病致全身炎症反应综合征患儿血C反应蛋白、VW因子的变化  

Changes of C-Reactive Protein and Von Willebrand Factor in Children with Systemic Inflammatory Response Syndrome Caused by Non-Infective Diseases

作　　者：付红敏[1] 王剑锋[1] 李平[1] 汤春辉[1] 

机构地区：[1]云南省第一人民医院儿科,昆明650032

出　　处：《实用儿科临床杂志》2006年第12期743-743,776,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的了解非感染性疾病所致全身炎症反应综合征(SIRS)患儿CRP和VW因子的变化及其意义。方法选择符合SIRS诊断标准的非感染性疾病患儿32例作为研究对象,根据是否发生多器官衰竭(MOF)分为MOF组(9例)和非MOF组(23例)。取其外周静脉血3 mL,分别用ELISA法和免疫比浊法测定血CRP和VW因子水平。20例正常儿童作对照。结果SIRS患儿血CRP和VW因子[37 mg/L,(185.50±27.71)%],显著高于对照组[8.5 mg/L,(134.60±20.64)%](P均<0.01);MOF组CRP和VW因子[109 mg/L,(213.79±23.70)%],显著高于非MOF组患儿[30 mg/L,(174.43±20.54)%](P均<0.01)。结论CRP和VW因子测定有助于判断非感染性疾病所致SIRS患儿的病情。Objective To explore the changes of C - reactive protein（CRP） and yon willebrand（VW） factor levels on pathogenesis of systemic inflammatory response syndrome （SIRS）caused by non - infective diseases in children. Methods Thirty - two children who attained to SIRS criterias caused by non- infective diseases were selected as study group,who were further divided into multiple organ failure（MOF）group and non - MOF group according to whether the patients had MOF. Blood samples were taken to measure VW factor and CRP by ELISA and immune turbidimetry respectively. Twenty health children were as control group. Results Concentrations of blood VW factor（37 mg/ L） and CRP[ （185.50 ±27.71 ）% ] were significantly higher in children with SIRS than those in control group（ all P〈 0.01 ）. In addition, CRP（ 109 mg/ L） and VW factor[ （213.79 ± 23.70） % ] levels on patients developed into MOF phase significantly increased compared with those non- MOF in study group（all P〈0.01）. Conclusion The detection of VW factor and CRP will be conductive to analyze the severity degree of disease in children with SIRS caused by non - infective diseases.

关 键 词：系统性炎症反应综合征 非感染性疾病 儿童 C反应蛋白 VW因子 

分 类 号：R720.597[医药卫生—急诊医学]