缺氧缺血性脑病新生儿脑型肌酸激酶同工酶、胱抑素C的变化及其临床意义  

Changes of Serum Brain Type Creatine Kinase Isoenzyme and Cystatin C in Neonates with Hypoxic-Ischemic Encephalopathy and Their Clinical Significance

作　　者：周明琪[1] 刘兰[1] 王宏[1] 李君霞[1] 

机构地区：[1]山东胜利油田中心医院儿科,山东东营257034

出　　处：《实用儿科临床杂志》2006年第12期753-753,770,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨HIE新生儿血清脑型肌酸激酶同工酶(CK-BB)、胱抑素C(CysC)的变化。方法对56例HIE患儿(轻、中、重度分别为18、19、19例)及42例正常新生儿用日本Olympus AU 1000全自动生化分析仪测定其血清CK-BB、CysC。结果1.中度HIE患儿血清CK-BB与对照组比较明显增高(P<0.05),重度与轻度组比较明显增高(P<0.05),重度组与对照组比较显著增高(P<0.01);各组HIE患儿CysC与对照组比较明显增高(P均<0.01),中重度HIE患儿与轻度组比较血清CysC均显著升高(P均<0.01)。2.新生儿血清CK-BB与CysC呈高度正相关(r=0.85 P<0.01)。结论联合检测血清CK-BB、CysC水平,可尽早发现HIE患儿的脑、肾损害。Objective To explore the changs of serum brain type creatine kinase isoenzyme （CK-BB）, cystatin C of newborns with hypoxic - ischemic encephalopathy（HIE） and assess their applications. Methods The serum concentrations of CK-BB and cystatin C were measured by turbidimertric immunoassay in 56 HIE newborns and 42 normal neonates. Results 1. Compared with controls , the concentration of serum CK-BB in moderate HIE newborns had significant differences（ P 〈 0.05） ; The same result lived in mild and severe HIE newborns（P〈0.05） ;Compared with controls , the concentration of serum cystatin C in HIE newborns had significant differences（ P〈 0.01 ） ; Compared with mild HIE newborns , the concentration of serum cystatin C in moderate severe HIE newborns had significant differences（P〈 0.01 ） ; 2. The relevant coefficient of CK-BB and serum cystatin C of newborns were obviously significant （ r = 0.85 P〈0.01） .Conclusion Serum CK-BB and cystatin C may be useful for assessment of brain and renal injury of children with HIE.

关 键 词：婴儿 新生 脑缺氧 脑缺血 磷酸肌酸激酶同工酶 胱抑素C 

分 类 号：R722.1[医药卫生—儿科]