神经元特异性烯醇化酶对脑膜炎患儿的诊断价值  

Diagnostic Value of Neuron-Specific Enolase in Children with Meningitis

作　　者：张秀芳[1] 孙昭辉[2] 孙若鹏[3] 

机构地区：[1]山东省千佛山医院儿科,济南250014 [2]山东大学第二医院检验科,济南250033 [3]山东大学齐鲁医院儿科,济南250012

出　　处：《实用儿科临床杂志》2006年第12期756-757,共2页Journal of Applied Clinical Pediatrics

基　　金：山东高等学校优秀科研成果二等奖(2004320189)

摘　　要：目的探讨脑脊液神经元特异性烯醇化酶(CSF-NSE)对脑膜炎患儿的诊断价值。方法采用ELISA对18例化脓性脑膜炎(化脑)、13例结核性脑膜炎(结脑)及25例病毒性脑膜炎(病脑)及18例正常儿童CSF-NSE进行测定。结果与对照组比较,化脑及结脑患儿CSF-NSE水平均显著升高(P均<0.05);病脑患儿无显著性差异(P>0.05);化脑及结脑患儿CSF-NSE水平较病脑患儿显著升高(P<0.05);化脑、结脑、病脑患儿CSF-NSE与其CSF白细胞数及蛋白水平均无相关性(P>0.05)。结论CSF-NSE测定可作为鉴别化脑和病脑的重要参考指标之一,也可作为评价脑膜炎患儿病情严重程度及预后的生化指标。Objective To explore the diagnostic value of neuron - specific enolase（NSE） in cerebrospinal fluid（CSF） in children with meningitis. Methods NSE levels in CSF of 18 children with purulent meningitis, 13 children with tuberculous meningitis and 25 children with viral meningitis were determined by enzyme - linked immunosorbent assay（ELISA）. Results CSF- NSE levels increased significantly in children with purulent meningitis and tuberculous meningitis compared with that of control group（ P 〈 0.05） ; CSF- NSE levels were found to have no significant differences between viral meningitis group and control group （P 〉 0.05 ）; CSF- NSE levels increased significantly in children with purulent meningitis and tuberculous meningitis, compared with that of viral meningitis group （ P〈 0.05） ; In cases of purulent meningitis, tuberculous and viral meningitis, there was no significant correlation between NSE and WBC, or between NSE and protein in CSF（all P 〉 0.05）. Conclusions The determination of the neuron - specific enolase in cerebrospinal fluid can be used as an important parameter for identifying bacterial meningitis from viral meningitis. It also can be used to estimate the severity and prognosis of meningitis in children.

关 键 词：神经元特异性烯醇化酶 脑膜炎 脑脊髓液 

分 类 号：R725.1[医药卫生—儿科]